Evidence map›Paper›PMID 23999524›Full record

ArticleMolecular psychiatry2014

Evidence for the role of EPHX2 gene variants in anorexia nervosa.

A A Scott-Van Zeeland, C S Bloss, R Tewhey, V Bansal, A Torkamani, O Libiger, V Duvvuri, N Wineinger, L Galvez, B F Darst and 37 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005129 active not recruitingnot on this map

The Bogalusa Heart Study

TypeobservationalSponsorTulane UniversityRan1973 to 2029Enrolled11,737ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
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  16. A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 20 institutions in 6 countries.

A A Scott-Van Zeeland1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
C S Bloss1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
R Tewhey1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
V Bansal1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
A Torkamani1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
O Libiger1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
V DuvvuriDepartment of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.
N Wineinger1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
L GalvezThe Scripps Translational Science Institute, La Jolla, CA, USA.
B F Darst1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
E N SmithDepartment of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.
A Carson1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
P Pham1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
T Phillips1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
N Villarasa1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
R Tisch1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
G Zhang1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.
S Levy1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
S Murray1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
W ChenDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
S SrinivasanDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
G BerensonDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
H BrandtDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
S CrawfordDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
S CrowDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
M M FichterRoseneck Hospital for Behavioral Medicine, Prien, Germany.
K A HalmiEating Disorder Research Program Weill Cornell Medical College, White Plains, NY, USA.
C JohnsonEating Recovery Center, Denver, CO, USA.
A S Kaplan1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
M La ViaDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J E Mitchell1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.
M StroberDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
A RotondoDepartment of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.
J TreasureDepartment of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.
D B Woodside1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.
C M Bulik1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
P KeelDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
K L KlumpDepartment of Psychology, Michigan State University, East Lansing, MI, USA.
L LilenfeldClinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC, USA.
K PlotnicovDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
E J Topol1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
P B ShihDepartment of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.
P MagistrettiLaboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne, Switzerland.
A W BergenCenter for Health Sciences, SRI International, Menlo Park, CA, USA.
W BerrettiniDepartment of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.
W KayeDepartment of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.
N J Schork1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Scripps Research Institute · USScripps Health · USUniversity of California, San Diego · USTulane University · USUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USArgosy University · USCentre for Addiction and Mental Health · CACornell University · USFlorida State University · USMichigan State University · USNeuropsychiatric Research Institute · USSchön Klinik Roseneck · DESRI International · USThe Recovery Center · USUniversity Health Network · CAUniversity of California, Los Angeles · USUniversity of Lausanne · CHUniversity of London · GBUniversity of Minnesota · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI JODI A LAPIDUS · 2004 to 2026
$102.6M
Quantitative Biology CoreU19AI063603 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHORK, NICHOLAS JOSEPH · 2004 to 2015
$26.4M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1995 to 2015
$17.0M
Deep sequencing studies for cannabis and stimulant dependenceR01DA030976 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EHLERS, CINDY L, GELERNTER, JOEL · 2010 to 2014
$16.5M
SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE (UL1)UL1RR025774 · NCRR · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2008 to 2011
$16.3M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
STATISTICS AND DATA MANAGEMENT COREP01AG027734 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SCHECHTER, CLYDE · 2007 to 2012
$9.3M
Genome Wide Association of Coronary Artery Disease and Related Risk FactorsR01HL089655 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROECKEL, ULRICH · 2008 to 2012
$3.8M
Genomic Predictors of Combat Stress Vulnerability and ResilienceR01MH093500 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M · 2011 to 2013
$2.7M
Solving EPHX2 and PUFA Interactions in Anorexia NervosaR01MH106781 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2016 to 2020
$2.0M
Scripps Genome ADVISER: Annotation and Distributed Variant Interpretation SERverU01HG006476 · NHGRI · SCRIPPS HEALTH · PI TORKAMANI, ALI · 2012 to 2015
$1.1M
Allele-specific Mapping in Alzheimer's DiseaseR01AG035020 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, TYCKO, BENJAMIN · 2010 to 2014
$592k
NCRR NIH HHS 5 UL1 RR025774NCRR NIH HHS UL1 RR025774NHGRI NIH HHS 1R21HG005747-01NHGRI NIH HHS R21 HG005747NHGRI NIH HHS U01 HG006476NHLBI NIH HHS 5 R01 HL089655NHLBI NIH HHS R01 HL089655NIAID NIH HHS 2 U19 AI063603NIAID NIH HHS U19 AI063603NIA NIH HHS 2 U19 AG023122NIA NIH HHS 5 P01AG027734NIA NIH HHS 5 R01 AG035020NIA NIH HHS P01 AG027734NIA NIH HHS R01 AG035020NIA NIH HHS U19 AG023122NIDA NIH HHS 5 R01 DA030976NIDA NIH HHS 5 U01 DA024417NIDA NIH HHS R01 DA030976NIDA NIH HHS U01 DA024417NIDDK NIH HHS 5K01DK087813-02NIDDK NIH HHS K01 DK087813NIDDK NIH HHS P30 DK050456NIMH NIH HHS 1 R01 MH093500NIMH NIH HHS R01 MH093500NIMH NIH HHS R01 MH106781
6 · The paper itself

Abstract

Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.

Indexed as

Genetic VariationAdultAnorexia NervosaBody Mass IndexCase-Control StudiesCholesterolCohort StudiesEpoxide HydrolasesFemaleGenetic Predisposition to DiseaseHumansLongitudinal StudiesMaleMiddle AgedPolymorphism, Single NucleotidePsychometricsCholesterolEPHX2 protein, humanEpoxide Hydrolases

Identifiers

PMID23999524
PMCPMC3852189
OpenAlexW2067983286

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.