ArticleThe Journal of experimental medicine2013
Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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Who cites it
51 citing papers in PubMed, 87 citations in OpenAlex.
- Uncovering a new player in ischemic stroke: a study of intra-arterial interferon-gamma-producing CD14Journal of neuroinflammation · 2026Article
- Context matters: Conflicting roles of interferon-γ signaling in CNS diseases.Current opinion in neurobiology · 2026Review
- Proteomics revealed the underlying mechanism of STAT1-induced cognitive deficits in 2-month-old C57 mice.Experimental brain research · 2025Article
- Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens.Acta neuropathologica · 2025Article
- T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis.Cell reports. Medicine · 2025Article
- [(Auto)immunity in focal epilepsy: mechanisms of (auto‑)immune-inflammatory epileptogenic neurodegeneration].Der Nervenarzt · 2024Review
- Orchestration of antiviral responses within the infected central nervous system.Cellular & molecular immunology · 2024Review
- Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain.Brain, behavior, and immunity · 2023Article
- Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis.Science advances · 2023Article
- A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain.The Journal of clinical investigation · 2023Article
- Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasiveFrontiers in immunology · 2023Article
- Unique aspects of IFN-γ/STAT1 signaling in neurons.Immunological reviews · 2022Review
- Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination.Genome medicine · 2022Article
- Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity.Genes and immunity · 2022Article
- Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV.Brain : a journal of neurology · 2022Article
- G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.Science advances · 2022Article
- Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8Molecular brain · 2022Article
- CD4Journal of neuroinflammation · 2022Article
- Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis.Annals of clinical and translational neurology · 2021Article
- The Neuroinflammatory Role of Pericytes in Epilepsy.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 4 countries.
Funding
Abstract
Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in vivo. In a viral encephalitis model in mice, disease depended on CTL-derived interferon-γ (IFN-γ) and neuronal IFN-γ signaling. Downstream STAT1 phosphorylation and nuclear translocation in neurons were associated with dendrite and synapse loss (deafferentation). Analogous molecular and structural alterations were also found in human Rasmussen encephalitis, a CTL-mediated human autoimmune disorder of the CNS. Importantly, therapeutic intervention by IFN-γ blocking antibody prevented neuronal deafferentation and clinical disease without reducing CTL responses or CNS infiltration. These findings identify neuronal IFN-γ signaling as a novel target for neuroprotective interventions in CTL-mediated CNS disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.