Evidence map›Paper›PMID 23998929›Full record

ReviewCurrent opinion in neurobiology2013

Exosomes function in cell-cell communication during brain circuit development.

Pranav Sharma, Lucio Schiapparelli, Hollis T Cline

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 119 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Astrocyte Modulation of Synaptic Plasticity Mediated by Activity-Dependent Sonic Hedgehog Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Review
  8. Review
  9. Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Extracellular Vesicles as Therapeutic Resources in the Clinical Environment.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Review
  19. iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes.International journal of molecular sciences · 2022
    Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Pranav SharmaDepartment of Molecular and Cellular Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
Lucio Schiapparelli
Hollis T Cline
Scripps Research Institute · US

Funding

Activity-dependent Development of Visual System DevelopmentR01EY011261 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 1996 to 2018
$11.1M
NIH Director's Pioneer Award (RMI)DP1OD000458 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2005 to 2009
$4.4M
Trans-Synaptic Transport of Endogenous Proteins to Label CircuitsR01MH091676 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2010 to 2013
$1.5M
Exosome-mediated cell-cell signaling in Rett SyndromeR01MH103134 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T., MUOTRI, ALYSSON R. · 2013 to 2016
$1.4M
Analysis of the Dynamic Synaptic ProteomeR21MH099799 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI CLINE, HOLLIS T. · 2012 to 2013
$512k
NEI NIH HHS EY011261NEI NIH HHS R01 EY011261NIH HHS DP1 OD000458NIH HHS DP5OD000458NIMH NIH HHS MH091676NIMH NIH HHS MH099799NIMH NIH HHS R01 MH091676NIMH NIH HHS R01 MH103134NIMH NIH HHS R21 MH099799
6 · The paper itself

Abstract

Exosomes are small extracellular vesicles that mediate intercellular signaling in the brain without requiring direct contact between cells. Although exosomes have been shown to play a role in neurological diseases and in response to nerve trauma, a role for exosome-mediated signaling in brain development and function has not yet been demonstrated. Here we review data building a case for exosome function in the brain.

Indexed as

AnimalsBrainCell CommunicationExosomesHumansNeural PathwaysNeurogenesis

Identifiers

PMID23998929
PMCPMC3830597
OpenAlexW2021836199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.