ArticleAging & mental health2014
APOE ϵ4, rated life experiences, and affect among centenarians.
Article in Aging & mental health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.Neuron · 2026Review
- From 70 to 100: The Kuakini Hawaii Centenarian Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet.GeroScience · 2025Review
- Healthy aging among centenarians and near-centenarians: Findings from the Georgia Centenarian Study.Maturitas · 2024Review
- A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.Journal of happiness studies · 2022Article
- Review
- Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.Current neuropharmacology · 2018Review
- Metabolic and Genetic Markers of Biological Age.Frontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
16 authors at 10 institutions in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to assess the relationship between apolipoprotein E (APOE), life events and engagement, and subjective well-being (as measured by positive and negative affect) among centenarians. Based on the life stress paradigm, we predicted that higher levels of stress would allow APOE to influence positive and negative affect.
method196 centenarians and near-centenarians (98 years and older) of the Georgia Centenarian Study participated in this research. The APOE, positive and negative affect, the number of recent (last 2 years) and lifelong (more than 20 years prior to testing) events, as well as a number of life engagement tasks were assessed.
resultsResults suggested that centenarians carrying the APOE ϵ4 allele rated lower in positive affect, the number of lifelong events, and in engaged lifestyle, when compared to centenarians without the APOE ϵ4 allele (t = 3.43, p < .01; t = 3.19, p < .01; and t = 2.33, p < .05, respectively). Blockwise multiple regressions indicated that the APOE ϵ4 predicted positive but not negative affect after controlling for demographics. Gene-environment interactions were obtained for the APOE ϵ4 and lifelong events, suggesting that carriers of the APOE ϵ4 allele had higher scores of negative affect after having experienced more events, whereas noncarriers had reduced negative affect levels after having experienced more events.
conclusionAPOE ϵ4 is directly related to positive affect and is related to negative affect in interaction with life events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.