ArticleJournal of cellular and molecular medicine2013
Identification of micro-RNA networks in end-stage heart failure because of dilated cardiomyopathy.
Article in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A meta-analysis of microRNA expression profiling studies in heart failure.Heart failure reviews · 2021Pooled it
- From Natriuretic Peptides to microRNAs: Multi-Analyte Liquid Biopsy Horizons in Heart Failure.Biomolecules · 2025Review
- Current Review of Heart Failure-Related Risk and Prognostic Factors.Biomedicines · 2024Review
- miR-340-5p Alleviates Oxidative Stress Injury by Targeting MyD88 in Sepsis-Induced Cardiomyopathy.Oxidative medicine and cellular longevity · 2022Article
- Circulating miR-19b-3p as a Novel Prognostic Biomarker for Acute Heart Failure.Journal of the American Heart Association · 2021Article
- Epigenetic Regulation of Cardiac Troponin Genes in Pediatric Patients with Heart Failure Supported by Ventricular Assist Device.Biomedicines · 2021Article
- Identification of novel circulating microRNAs in advanced heart failure by next-generation sequencing.ESC heart failure · 2021Article
- A three-tiered integrative analysis of transcriptional data reveals the shared pathways related to heart failure from different aetiologies.Journal of cellular and molecular medicine · 2020Article
- Reverse Cardio-Oncology: Cancer Development in Patients With Cardiovascular Disease.Journal of the American Heart Association · 2020Review
- A novel system-level approach using RNA-sequencing data identifies miR-30-5p and miR-142a-5p as key regulators of apoptosis in myocardial infarction.Scientific reports · 2018Article
- Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA-1.Journal of cellular and molecular medicine · 2018Article
- In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge.Journal of visualized experiments : JoVE · 2018Article
- Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4The Journal of biological chemistry · 2017Article
- Role of microRNA in metabolic shift during heart failure.American journal of physiology. Heart and circulatory physiology · 2017Review
- Mitochondria Associated MicroRNA Expression Profiling of Heart Failure.BioMed research international · 2017Article
- MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes.Archives of toxicology · 2016Article
- Epigenetic regulation in heart failure.Current opinion in cardiology · 2016Review
- Differential microRNA Expression and Regulation in the Rat Model of Post-Infarction Heart Failure.PloS one · 2016Article
- MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells.Journal of cellular and molecular medicine · 2015Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-RNAs regulate gene expression by directly binding to the target mRNAs. The goal of the study was to examine the expression profiling of miRNAs in human failing hearts and identify the key miRNAs that regulate molecular signalling networks and thus contribute to this pathological process. The levels of miRNAs and expressed genes were analysed in myocardial biopsy samples from patients with end-stage heart failure (n = 14) and those from normal heart samples (n = 8). Four networks were built including the Gene regulatory network, Signal-Network, miRNA-GO-Network and miRNA-Gene-Network. According to the fold change in the network and probability values in the microarray cohort, RT-PCR was performed to measure the expression of five of the 72 differentially regulated miRNAs. miR-340 achieved statistically significant. miR-340 was identified for the first time in cardiac pathophysiological condition. We overexpressed miR-340 in cultured neonatal rat cardiomyocytes to identify whether miR-340 plays a determining role in the progression of heart failure. ANP, BNP and caspase-3 were significantly elevated in the miR-340 transfected cells compared with controls (P < 0.05). The cross-sectional area of overexpressing miR-340 cardiomyocytes (1952.22 ± 106.59) was greater (P < 0.0001) than controls (1059.99 ± 45.59) documented by Laser Confocal Microscopy. The changes of cellular structure and the volume were statistical significance. Our study provided a comprehensive miRNA expression profiling in the end-stage heart failure and identified miR-340 as a key miRNA contributing to the occurrence and progression of heart failure. Our discoveries provide novel therapeutic targets for patients with heart failure.
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Registered trials
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