ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2013
Risk of uterine cancer in symptomatic women in primary care: case-control study using electronic records.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Development, validation and effectiveness of diagnostic prediction tools for colorectal cancer in primary care: a systematic review.BMC cancer · 2020Pooled it
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Is real world evidence influencing practice? A systematic review of CPRD research in NICE guidances.BMC health services research · 2016Pooled it
- Cancer risk in patients with recurrent or persistent symptoms: a systematic review.The Lancet regional health. Europe · 2026Review
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- The Clinical Value of Pre-Diagnostic Thrombocytosis for the Detection of Lung Cancer in Primary Care.Cancers · 2024Article
- Black-White differences in uterine cancer symptomatology and stage at diagnosis.Gynecologic oncology · 2024Article
- Symptoms and signs of urogenital cancer in primary care.BMC primary care · 2023Article
- Diagnosis of Peritoneal Carcinomatosis of Colorectal Origin Based on an Innovative Fuzzy Logic Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Is concern for gynaecological alarm symptoms associated with healthcare-seeking? A Danish population-based cross-sectional study.BMC public health · 2022Article
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- Quadruple synchronous primary cancers in a single patient.BMJ case reports · 2020Article
- Availability and use of cancer decision-support tools: a cross-sectional survey of UK primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Evaluation of Hospital-Based Hematuria Diagnosis and Subsequent Cancer Risk Among Adults in Denmark.JAMA network open · 2018Article
- Recognizing Gynecological Cancer in Primary Care: Risk Factors, Red Flags, and Referrals.Advances in therapy · 2018Article
- Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data.The British journal of general practice : the journal of the Royal College of General Practitioners · 2017Article
- Article
- For which cancers might patients benefit most from expedited symptomatic diagnosis? Construction of a ranking order by a modified Delphi technique.BMC cancer · 2015Article
- Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
- Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.The British journal of general practice : the journal of the Royal College of General Practitioners · 2015Article
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3 authors.
Funding
Abstract
backgroundUterine cancer is the fourth most common cancer in women in the UK, with approximately 7700 new diagnoses and 1700 deaths annually.
aimTo identify and quantify features of uterine cancer in primary care. DESIGN AND
settingCase-control study using electronic primary care records in primary care in the UK.
methodPutative features of uterine cancer were identified in the year before diagnosis, and odds ratios (ORs) calculated using conditional logistic regression. Positive predictive values (PPVs) were calculated for women who consulted.
resultsA total of 2732 women aged ≥40 years with uterine cancer between 2000 and 2009, and 9537 age-, sex- and practice-matched controls were selected from the General Practice Research Database. The median age at diagnosis was 67 years. Nine features were significantly associated with uterine cancer: postmenopausal bleeding (OR = 160; 95% confidence interval [CI] = 100 to 240), excessive vaginal bleeding (OR = 22; 95% CI = 12 to 42), irregular menstruation (OR = 42; 95% CI = 27 to -63), vaginal discharge (OR = 14; 95% CI = 10 to 21), haematuria (OR = 8.7; 95% CI = 5.0 to 15), abdominal pain (OR = 2.0; 95% CI = 1.4 to 2.8), low haemoglobin (OR = 2.1; 95% CI = 1.5 to 2.9), raised platelets (OR = 1.5; 95% CI = 1.0 to 2.3), and raised glucose (OR = 1.4; 95% CI = 1.1 to 1.8); all P<0.01, other than raised platelets, P = 0.05 and raised glucose, P = 0.02. In the year before diagnosis, 1725 (63%) cases had a record of abnormal vaginal bleeding compared to 135 (1%) controls. The PPV of uterine cancer with postmenopausal bleeding was 4%, and was higher in women with multiple or repeated symptoms.
conclusionThis study confirms the importance of several features, particularly postmenopausal bleeding, for uterine cancer. Haematuria is an important risk marker. The results of this study may inform GPs in the selection of women for investigation and should assist the NICE in their update of GP referral guidance.
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