ArticleJournal of diabetes research2013
Pronerve growth factor induces angiogenesis via activation of TrkA: possible role in proliferative diabetic retinopathy.
Article in Journal of diabetes research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Stress-Induced Changes in Trophic Factor Expression in the Rodent Urinary Bladder: Possible Links With Angiogenesis.International neurourology journal · 2022Article
- The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Modulation of p75International journal of molecular sciences · 2021Article
- Antagonism of proNGF or its receptor p75Diabetologia · 2020Article
- Article
- Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis.Journal of cellular and molecular medicine · 2019Article
- CD140b (PDGFRβ) signaling in adipose-derived stem cells mediates angiogenic behavior of retinal endothelial cells.Regenerative engineering and translational medicine · 2019Article
- Deletion of p75Scientific reports · 2018Article
- Implication of the neurotrophin receptor p75Expert review of ophthalmology · 2017Article
- Deletion of the Neurotrophin Receptor p75Journal of diabetes, metabolic disorders & control · 2017Article
- NGF increases VEGF expression and promotes cell proliferation via ERK1/2 and AKT signaling in Müller cells.Molecular vision · 2016Article
- Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?Omics : a journal of integrative biology · 2015Review
- Imbalance of the nerve growth factor and its precursor as a potential biomarker for diabetic retinopathy.BioMed research international · 2015Article
- Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes.Diabetes & metabolism journal · 2014Review
- Nerve growth factor in diabetic retinopathy: beyond neurons.Expert review of ophthalmology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans. We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF. Increases in proNGF were positively correlated with progression of diabetic retinopathy, having the highest level in ocular fluids from PDR patients compared to nondiabetic patients. Here, we attempted to evaluate the contribution and the possible mechanism of proNGF to PDR. The angiogenic response of aqueous humor samples from PDR patients was examined in human retinal endothelial cells in the presence or absence of anti-proNGF antibody. Additional cultures were treated with mutant-proNGF in the presence of specific pharmacological inhibitors of TrkA and p75(NTR) receptors. PDR-aqueous humor samples exerted significant angiogenic response including cell proliferation, migration, and alignment into tube-like structures. These effects were significantly reduced by anti-proNGF antibody but not by IgG. Treatment of retinal endothelial cells with mutant-proNGF activated phosphorylation of TrkA and p38MAPK; however, it did not alter p75(NTR) expression. Inhibition of TrkA but not p75(NTR) significantly reduced mutant-proNGF-induced cell proliferation, cell migration, and tube formation. Taken together, these results provide evidence that proNGF can contribute to PDR at least in part via activation of TrkA.
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Registered trials
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