ArticleJournal of clinical and diagnostic research : JCDR2013
A study of serum apolipoprotein A1, apolipoprotein B and lipid profile in stroke.
Article in Journal of clinical and diagnostic research : JCDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- High Apolipoprotein B Levels are Associated with an Increased Risk of Recurrent Acute Ischemic Stroke: A Nested Case-Control Study.Translational stroke research · 2025Article
- Article
- Predictive value of the apolipoprotein B/A1 ratio in intracerebral hemorrhage outcomes.Journal of clinical laboratory analysis · 2022Article
- Article
- Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes.Frontiers in molecular biosciences · 2021Article
- Acute Stroke Biomarkers: Are We There Yet?Frontiers in neurology · 2021Review
- Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects.Journal of cardiovascular and thoracic research · 2020Article
- Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Observational
- Deeper insight into chronic kidney disease-related atherosclerosis: comparative proteomic studies of blood plasma using 2DE and mass spectrometry.Journal of translational medicine · 2015Article
- Impact of corpulence parameters and haemoglobin A1c on metabolic control in type 2 diabetic patients: comparison of apolipoprotein B/A-I ratio with fasting and postprandial conventional lipid ratios.The Libyan journal of medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRole of Serum Lipids, Lipoproteins and Lipoprotein related variables in the prediction of Stroke is less clear. Abnormalities in plasma Lipoproteins are the most firmly established and best understood risk factors for Atherosclerosis and they are probable risk factors for Ischaemic stroke, largely by their link to Atherosclerosis. Apo B reflects the concentration of potentially atherogenic particles (LDL), and Apo A1 reflects the corresponding concentration of anti- atherogenic particles (HDL), represent additional lipoprotein related variables that may indicate the vascular risk.
aimTo study serum concentration of Apolipoprotein A1, Apolipoprotein B, Apo B/Apo A1 ratio and Lipid profile in Stroke Cases and to compare with healthy controls.
designA total number of 100 subjects within 30 - 70 years were considered for the study. 50 subjects with Stroke (both clinically as well as Computed tomographically proven cases) and 50 age and sex matched healthy individuals were taken for the study. MATERIAL AND
methodsTotal cholesterol, HDL cholesterol and Triglycerides are estimated by Enzymatic method using Semiautoanalyser. LDL cholesterol is estimated by Friedewald formula. Apo B and Apo A1 are estimated by Immunoturbidimetric method using Semiautoanalyser. STATISTICAL ANALYSIS: Student 't' test was used to compare the data between cases and controls. Diagnostic validity tests were conducted to assess the Diagnostic efficiency of Apo A1, Apo B and Apo B/Apo A1 ratio.
resultsTotal cholesterol, LDL cholesterol and Triglycerides are significantly increased in Cases compared to Controls. HDL - cholesterol is significantly decreased in Cases compared to Controls. Apo B and Apo B/Apo A1 ratio are significantly increased and Apo A1 is significantly decreased in Cases compared to Controls. Diagnostic validity tests showed that, Apo B , Apo A1 and Apo B /Apo A1 ratio have highest Sensitivity, Specificity and Diagnostic efficiency.
conclusionApo B , Apo A1 and Apo B / Apo A1 ratio can be used as predictors of stroke along with traditional lipid profile components.
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