ArticleAsian Pacific journal of tropical biomedicine2013
Pharmacological potential of Populus nigra extract as antioxidant, anti-inflammatory, cardiovascular and hepatoprotective agent.
Article in Asian Pacific journal of tropical biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
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- Chemical Composition, Antioxidant Activity, and Antibacterial Activity of Black Poplar Buds' Hydroalcoholic Macerates from Dobrogea Area.Molecules (Basel, Switzerland) · 2023Article
- Protective effects ofNutrition research and practice · 2022Article
- Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract.BMC complementary medicine and therapies · 2022Article
- Antioxidant-Anti-Inflammatory Evaluation of a Polyherbal Formula.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Article
- Extracts of Poplar Buds (Plants (Basel, Switzerland) · 2021Article
- Antioxidant Activity and Chemical Characteristics of Supercritical COMolecules (Basel, Switzerland) · 2021Article
- Recent Advances Regarding the Phytochemical and Therapeutic Uses ofPlants (Basel, Switzerland) · 2020Review
- Stronger antioxidant enzyme immunoreactivity ofIranian journal of basic medical sciences · 2019Article
- Pre-treatedAnatomy & cell biology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate antioxidant, anti-inflammatory, hepatoprotective and vasorelaxant activities of Populus nigra flower buds ethanolic extract.
methodsAntioxidant and anti-inflammatory activities of the extract were assessed using respectively the ABTS test and the animal model of carrageenan-induced paw edema. Protection from hepatic toxicity caused by aluminum was examined by histopathologic analysis of liver sections. Vasorelaxant effect was estimated in endothelium-intact and -rubbed rings of porcine coronary arteries precontracted with high concentration of U46619.
resultsThe results showed a moderate antioxidant activity (40%), but potent anti-inflammatory activity (49.9%) on carrageenan-induced mice paw edema, and also as revealed by histopathologic examination, complete protection against AlCl₃-induced hepatic toxicity. Relaxant effects of the same extract on vascular preparation from porcine aorta precontracted with high concentration of U46619 were considerable at 10⁻¹ g/L, and comparable (P>0.05) between endothelium-intact (67.74%, IC₅₀=0.04 mg/mL) and -rubbed (72.72%, IC₅₀=0.075 mg/mL) aortic rings.
conclusionsThe extract exerted significant anti-inflammatory, hepatoprotective and vasorelaxant activities, the latter being endothelium-independent believed to be mediated mainly by the ability of components present in the extract to exert antioxidant properties, probably related to an inhibition of Ca²⁺ influx.
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