Evidence map›Paper›PMID 23997991›Full record

ArticleAsia-Pacific journal of ophthalmology (Philadelphia, Pa.)

Genetic and Epigenetic Regulation in Age-related Macular Degeneration.

Lai Wei, Ping Chen, Joo Hyun Lee, Robert B Nussenblatt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lai WeiLaboratory of Immunology, National Eye Institute, Bethesda, MD 20892, USA ; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA ; Zhongshan Ophthalmic Center, Guangzhou, China.
Ping Chen
Joo Hyun Lee
Robert B Nussenblatt
National Eye Institute · US

Funding

Effect of Acupuncture on Epigenetic Regulation of Inflammatory Mediators in PatieZIAAT000015 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI WEI, LAI · 2011 to 2013
$4.5M
Cellular and molecular mechanisms in Age Related Macular Degeneration & UveitisZIAEY000464 · NEI · NATIONAL EYE INSTITUTE · PI CHAIGNE-DELALANDE, BENJAMIN · 2009 to 2016
$2.4M
Use Of Microarrays and Epigenetics In Gene Expression Of Uveitis & AMD PatientsZIAEY000376 · NEI · NATIONAL EYE INSTITUTE · PI CHAIGNE-DELALANDE, BENJAMIN · 2009 to 2016
$2.1M
Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA AT000015
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the older population worldwide. While strong genetic risk factors have been associated with AMD etiology, environmental influences through epigenetic regulation are also likely to play a role. Recent advances in epigenetic studies have resulted in the development of numerous epigenetic drugs for the treatment of cancer and inflammation. Here, we review the current literature on the genetic and epigenetic mechanisms of AMD and suggest that understanding the cooperation of epigenetic and genetic mechanisms will greatly advance the clinical management of AMD.

Identifiers

PMID23997991
PMCPMC3755470
OpenAlexW2010466103

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.