ArticleIranian journal of basic medical sciences2013
Evaluation of the Effects of Caffeic Acid Phenethyl Ester on Prostaglandin E2 and Two Key Cytokines Involved in Bleomycin-induced Pulmonary Fibrosis.
Article in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review.Drug design, development and therapy · 2021Pooled it
- Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.Exploration (Beijing, China) · 2025Article
- NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye.Frontiers in immunology · 2025Article
- Article
- The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases.Medicinal research reviews · 2022Review
- Antioxidant effect of caffeic acid phenethyl ester in experimentally induced periodontitis.Clinical oral investigations · 2021Article
- Citrus Alkaline Extract Delayed the Progression of Pulmonary Fibrosis by Inhibiting p38/NF-κB Signaling Pathway-Induced Cell Apoptosis.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents.Bioscience reports · 2018Article
- Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection.Veterinary world · 2018Article
- Expression of vascular endothelial growth factor and matrix metalloproteinase-9 inVeterinary world · 2018Article
- Probing into the Mechanism of Alkaline Citrus Extract Promoted Apoptosis in Pulmonary Fibroblasts of Bleomycin-Induced Pulmonary Fibrosis Mice.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis.Inflammopharmacology · 2017Article
- Parasite Killing ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats.Pulmonary medicine · 2016Article
- Hydro-alcoholic extract of Raphanus sativus L. var niger attenuates bleomycin-induced pulmonary fibrosis via decreasing transforming growth factor β1 level.Research in pharmaceutical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): Pulmonary fibrosis (PF) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. It is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of PF in animal models and possibly in humans. Caffeic acid phenethyl ester (CAPE), an active component of propolis, has numerous biological effects. In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-β1, TNF-α and prostaglandin E2 (PGE2) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF). MATERIALS AND
methodsIn this study, forty male Sprague-Dawley rats were divided into 5 groups (n=8). (1) "Bleomycin (BLM)-treated (Model) group": BLM (5 mg/kg, single intratracheal dose), (2) "Saline-treated group": the rats were given only saline, (3) "Treatment-1 group": BLM + CAPE (5 μmol/kg/day, 28 days, IP), (4) "Treatment-2 group": BLM + CAPE (10 μmol/kg/day, 28 days, IP) and (5) "Vehicle + CAPE group": CAPE (10 μmol/kg/day, 28 days, IP).
resultsBLM could significantly increase the levels of TNF-α and TGF-β1 and decrease the PGE2 concentration compared to the saline control group. CAPE could considerably improve these values almost close to normal levels.
conclusionBriefly, CAPE can be suggested as a novel, attractive and effective agent for prevention and treatment of pulmonary fibrosis.
Indexed as
Identifiers
23997916PMC3758057W1499752510What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.