ArticleNeurodegenerative disease management2013
Neuropsychiatric symptoms in primary progressive aphasia: phenomenology, pathophysiology, and approach to assessment and treatment.
Article in Neurodegenerative disease management, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Premorbid de novo artistic creativity in frontotemporal dementia (FTD) syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- Neuropsychiatric Symptoms in Primary Progressive Aphasia: Phenomenology, Circuits, and Clinical Management.Current neurology and neuroscience reports · 2026Review
- A Longitudinal Analysis of Frontotemporal Dementia Patients in Spain throughout the COVID-19 Pandemic: A Descriptive Study.Dementia and geriatric cognitive disorders · 2026Article
- Non-fluent agrammatic variant of primary progressive aphasia in a bilingual Mandarin/English speaker: a case report.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Written picture descriptions distinguish variants of primary progressive aphasia.Journal of Alzheimer's disease : JAD · 2025Article
- Picture Description and Functional Communication Rating Correlates in Variants of Primary Progressive Aphasia.Aphasiology · 2025Article
- Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study.Brain sciences · 2024Article
- Association of Regional Cortical Network Atrophy With Progression to Dementia in Patients With Primary Progressive Aphasia.Neurology · 2023Article
- The Media Coverage of Bruce Willis Reveals Unfamiliarity With Frontotemporal Degeneration.Innovation in aging · 2023Article
- Altered within- and between-network functional connectivity in atypical Alzheimer's disease.Brain communications · 2023Article
- Medial Temporal Lobe Tau Aggregation Relates to Divergent Cognitive and Emotional Empathy Abilities in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Functional Disabilities and Psychiatric Symptoms in Primary Progressive Aphasia.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Application of the dual stream model to neurodegenerative disease: Evidence from a multivariate classification tool in primary progressive aphasia.Aphasiology · 2022Article
- Clinical and neuroimaging characteristics of primary progressive aphasia.Handbook of clinical neurology · 2022Review
- Cognitive and Neural Mechanisms of Social Communication Dysfunction in Primary Progressive Aphasia.Brain sciences · 2021Article
- Anhedonia in Semantic Dementia-Exploring Right Hemispheric Contributions to the Loss of Pleasure.Brain sciences · 2021Article
- Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia.Brain and language · 2019Article
- Rapid rate on quasi-speech tasks in the semantic variant of primary progressive aphasia: A non-motor phenomenon?The Journal of the Acoustical Society of America · 2018Article
- A Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival.Annals of clinical and translational neurology · 2017Article
- Case 1-2017. A 70-Year-Old Woman with Gradually Progressive Loss of Language.The New England journal of medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious and progressive loss of language. Current diagnostic criteria require symptoms to be largely restricted to language dysfunction for at least the first 2 years of the syndrome. However, as the disorder progresses - and sometimes even in the early stages - patients with PPA may exhibit neuropsychiatric symptoms. In this article, we review the phenomenology and frequency of neuropsychiatric symptoms in PPA. Among the few studies of this topic that have been performed, there is consistent agreement that neuropsychiatric symptoms are not uncommon among PPA patients. In some cases, particularly the semantic variant of PPA, symptoms are similar to those found in the behavioral variant of frontotemporal dementia. We further review the approach to assessment of behavioral symptoms in PPA and their possible management strategies, and speculate regarding their potential neurobiological substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.