Evidence map›Paper›PMID 23997776›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2012

Interferon-gamma release assays are a better tuberculosis screening test for hemodialysis patients: A study and review of the literature.

J Grant, J Jastrzebski, J Johnston, A Stefanovic, J Jastrabesky, K Elwood, D Roscoe, R Balshaw, E Bryce

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients.Journal of clinical tuberculosis and other mycobacterial diseases · 2022
    Article
  6. Agreement between the results of tuberculin skin test and Interferon-Gamma Release Assays in renal transplant candidates.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
    Article
  7. Article
  8. Interferon-gamma response to the treatment of active pulmonary and extra-pulmonary tuberculosis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
    Observational
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

J GrantDivision of Medical Microbiology, Department of Pathology and Laboratory Medicine;
J Jastrzebski
J Johnston
A Stefanovic
J Jastrabesky
K Elwood
D Roscoe
R Balshaw
E Bryce
Vancouver General Hospital · CABC Centre for Disease Control · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diagnosing latent tuberculosis (TB) infection (LTBI) in dialysis patients is complicated by poor response to tuberculin skin testing (TST), but the role of interferon-gamma release assays (IGRAs) in the dialysis population remains uncertain. Seventy-nine patients were recruited to compare conventional diagnosis (CD) with the results of two IGRA tests in a dialysis unit. Combining TST, chest x-ray and screening questionnaire results (ie, CD) identified 24 patients as possible LTBI. IGRA testing identified 22 (QuantiFERON Gold IT, Cellestis, USA) and 23 (T-spot.TB, Oxford Immunotec, United Kingdom) LTBI patients. IGRA and CD correlated moderately (κ=0.59). IGRA results correlated with history of TB, TB contact and birth in an endemic country. TST was not helpful in identifying LTBI patients in this population. The tendency for IGRAs to correlate with risk factors for TB, active TB infection and history of TB argues for their superiority over TST in dialysis patients. There was no superiority of one IGRA test over another.

Indexed as

DialysisHostImmunocompromisedInterferon-gamma release assayLatent tuberculosis infectionTuberculin skin testingTuberculosis

Identifiers

PMID23997776
PMCPMC3476553
OpenAlexW130647166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.