Evidence map›Paper›PMID 23997575›Full record

ArticleHepatic medicine : evidence and research2010

Hypothesis: Targeted

Katherine S Koch, Hyam L Leffert

Open access · goldAbstract read
In one paragraph

Article in Hepatic medicine : evidence and research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. CD4Frontiers in immunology · 2022
    Review
  2. Nutrients · 2020
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Katherine S KochHepatocyte Growth Control and Stem Cell Laboratory, Department of Pharmacology, School of Medicine, University of California, San Diego, CA, USA.
Hyam L Leffert
University of California, San Diego · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
IKKbeta:Bi-Functional Regulator of Hepatocyte ProliferationR01CA113602 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEFFERT, HYAM L · 2007 to 2010
$1.2M
Properties of Immune-Privileged STO-Progenitor CellsR21AI067354 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEFFERT, HYAM L · 2007 to 2008
$421k
NCI NIH HHS R01 CA113602NIAID NIH HHS R21 AI067354NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

Macrophage migration inhibitory factor (MIF) is causally related to the pathogenesis of chronic liver disease but its hepatocellular mechanisms of action are largely unknown. Scattered reports in the literature hint at functional connections between the expression of MIF and major histocompatibility complex (MHC) Class II molecules. Not surprisingly, these relationships have not yet been explored in hepatocytes because MIF and MHC Class II cell surface receptors are commonly expressed by other cell types including various antigen presenting cells of the immune system. On the other hand, mounting evidence suggests that heteromeric MIF receptors share a common molecule with intracellular MHC Class II complexes,

Indexed as

carcinomahepatocellular toxicityimmunityinflammation

Identifiers

PMID23997575
PMCPMC3756905
OpenAlexW2096460853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.