Evidence map›Paper›PMID 23997374›Full record

ArticleJournal of the American Statistical Association2011

A regularized Hotelling's

Lin S Chen, Debashis Paul, Ross L Prentice, Pei Wang

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. A Regularized MANOVA Test for Semicontinuous High-Dimensional Data.Biometrical journal. Biometrische Zeitschrift · 2025
    Article
  3. Article
  4. Article
  5. Finite sample t-tests for high-dimensional means.Journal of multivariate analysis · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Feature Screening via Distance Correlation Learning.Journal of the American Statistical Association · 2012
    Article
  13. Modified TTrends in hearing
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lin S ChenDepartment of Health Studies, The University of Chicago, IL.
Debashis Paul
Ross L Prentice
Pei Wang

Funding

Use of Biomarkers in Diagnosis, Prognosis, Risk Prediction and Early Detection ofP01CA053996 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSU, LI · 1991 to 2015
$9.4M
Statistical Methods for Integrative Analysis of Genomics and Proteomics DataR01GM082802 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI WANG, PEI · 2008 to 2012
$1.4M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
NCI NIH HHS P01 CA053996NIGMS NIH HHS R01 GM082802WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

Recent proteomic studies have identified proteins related to specific phenotypes. In addition to marginal association analysis for individual proteins, analyzing pathways (functionally related sets of proteins) may yield additional valuable insights. Identifying pathways that differ between phenotypes can be conceptualized as a multivariate hypothesis testing problem: whether the mean vector

Indexed as

Hotelling’s T2pathway analysisproteomicsregularization

Identifiers

PMID23997374
PMCPMC3755504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.