Trial reportSleep2013
Oral appliance versus continuous positive airway pressure in obstructive sleep apnea syndrome: a 2-year follow-up.
Trial report in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517150 (Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III), which is not on this map. Cited by 72 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficiency of Intraoral Appliance in the Treatment of Obstructive Sleep Apnea Syndrome in Obese Class III
Who cites it
72 citing papers in PubMed, 6 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Pooled it
- European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2021Guideline
- Side effects of mandibular advancement splints for the treatment of snoring and obstructive sleep apnea: a systematic review.Dental press journal of orthodontics · 2018Pooled it
- Trends in CPAP adherence over twenty years of data collection: a flattened curve.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2016Pooled it
- Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea.Sleep medicine reviews · 2016Pooled it
- Reconsidering first-line treatment for obstructive sleep apnea: a systematic review of the literature.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2016Pooled it
- The effects of continuous positive airway pressure and mandibular advancement therapy on metabolic outcomes of patients with mild obstructive sleep apnea: a randomized controlled study.Sleep & breathing = Schlaf & Atmung · 2021Trial
- The effects of mandibular advancement appliance therapy on jaw-closing muscle activity during sleep in patients with obstructive sleep apnea: a 3-6 months follow-up.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Randomized crossover study of tongue-retaining device and positive airway pressure for obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Long-term obstructive sleep apnea therapy: a 10-year follow-up of mandibular advancement device and continuous positive airway pressure.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Clinical- and Cost-Effectiveness of a Mandibular Advancement Device Versus Continuous Positive Airway Pressure in Moderate Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Trial
- Noncontact identification of sleep-disturbed breathing from smartphone-recorded sounds validated by polysomnography.Sleep & breathing = Schlaf & Atmung · 2019Trial
- A Randomized Crossover Trial Evaluating Continuous Positive Airway Pressure Versus Mandibular Advancement Device on Health Outcomes in Veterans With Posttraumatic Stress Disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Trial
- Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial on psychological distress.Clinical oral investigations · 2017Trial
- Long-term efficacy of an oral appliance in early treated patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2016Trial
- Comparison of effects of OSA treatment by MAD and by CPAP on cardiac autonomic function during daytime.Sleep & breathing = Schlaf & Atmung · 2016Trial
- Feasibility and impact of personalized therapy for obstructive sleep apnea in patients with acute coronary syndrome: a pilot randomized controlled trial.Pilot and feasibility studies · 2026Article
- Mandibular Advancement for Obstructive Sleep Apnea: Efficacy and the Trade-off of Expiratory Velopharyngeal Obstruction During Sleep Endoscopy - An Exploratory Observational Study.Nature and science of sleep · 2026Article
- Objective adherence to oral appliance therapy in patients with obstructive sleep apnea: a one-year longitudinal analysis.European journal of orthodontics · 2025Article
- Predictors of disease alleviation with mandibular advancement devices in obstructive sleep apnea: a retrospective cohort study.Head & face medicine · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesOral appliance therapy has emerged as an important alternative to continuous positive airway pressure (CPAP) in treating patients with obstructive sleep apnea syndrome (OSAS). In this study we report about the subjective and objective treatment outcome of oral appliance therapy and CPAP in patients with OSAS.
designCohort study of a previously conducted randomized clinical trial.
settingUniversity Medical Center, Groningen, The Netherlands. PATIENTS OR
participantsOne hundred three patients with OSAS.
interventionsCPAP and oral appliance therapy (Thornton Adjustable Positioner type-1, Airway Management, Inc., Dallas, TX, USA). MEASUREMENTS AND
resultsObjective (polysomnography) and subjective (Epworth Sleepiness Scale, Functional Outcomes of Sleep Questionnaire, Medical Outcomes Study 36-item Short Form Health Survey [SF-36]) parameters were assessed after 1 and 2 years of treatment. Treatment was considered successful when the apnea-hypopnea index (AHI) was < 5 or showed substantial reduction, defined as reduction in the index of at least 50% from the baseline value to a value of < 20 in a patient without OSAS symptoms while undergoing therapy. Regarding the proportions of successful treatments, no significant difference was found between oral appliance therapy and CPAP in treating mild to severe OSAS in a 2-year follow-up. More patients (not significant) dropped out under oral appliance therapy (47%) compared with CPAP (33%). Both therapies showed substantial improvements in polysomnographic and neurobehavioral outcomes. However, CPAP was more effective in lowering the AHI and showed higher oxyhemoglobin saturation levels compared to oral appliance therapy (P < 0.05).
conclusionsOral appliance therapy should be considered as a viable treatment alternative to continuous positive airway pressure (CPAP) in patients with mild to moderate obstructive sleep apnea syndrome (OSAS). In patients with severe OSAS, CPAP remains the treatment of first choice. CLINICAL TRIAL INFORMATION: The original randomized clinical trial, of which this study is a 2-year follow-up, is registered at ISRCTN.org; identifier: ISRCTN18174167; trial name: Management of the obstructive sleep apnea-hypopnea syndrome: oral appliance versus continuous positive airway pressure therapy; URL: http://www.controlled-trials.com/ISRCTN18174167.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.