Evidence map›Paper›PMID 23997313›Full record

ArticleTetrahedron2013

An unexpected copper catalyzed 'reduction' of an arylazide to amine through the formation of a nitrene intermediate.

Hanjing Peng, Kednerlin H Dornevil, Alexander B Draganov, Weixuan Chen, Chaofeng Dai, William H Nelson, Aimin Liu, Binghe Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanjing Peng *Department of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
Kednerlin H Dornevil *Department of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
Alexander B DraganovDepartment of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
Weixuan ChenDepartment of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
Chaofeng DaiDepartment of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
William H NelsonDepartment of Physics and Astronomy, Georgia State University, P.O. Box 4106, Atlanta, Georgia 30302-4106, USA.
Aimin LiuDepartment of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.
Binghe WangDepartment of Chemistry, Center for Biotechnology and Drug Design, and Center for Diagnostics and Therapeutics, Georgia State University, P.O. Box 3965, Atlanta, Georgia 30302-3965, USA.

Funding

Selection of Boronic Acid-modified Aptamers for GlycoproteinsR01GM084933 · NIGMS · GEORGIA STATE UNIVERSITY · PI WANG, BINGHE · 2008 to 2011
$1.2M
Aptamer-based Glycomics ToolsR42GM086925 · NIGMS · ECHELON BIOSCIENCES, INC. · PI WANG, BINGHE · 2009 to 2010
$555k
NIGMS NIH HHS R01 GM084933NIGMS NIH HHS R42 GM086925
6 · The paper itself

Abstract

Azido nitrobenzoxadiazole (NBD) was observed to undergo a 'reduction' reaction in the absence of an obvious reducing agent, leading to amine formation. In the presence of an excess amount of DMSO, a sulfoxide conjugate was also formed. The ratio of these two products was both temperature- and solvent-dependent, with the addition of water significantly enhancing the ratio of the 'reduction' product. Two intermediates of the azido-NBD reaction in DMSO were trapped and characterized by low-temperature EPR spectroscopy. One was an organic free radical (

Indexed as

AzideEPRNBDNitreneReduction

Identifiers

PMID23997313
PMCPMC3752911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.