ArticleCoordination chemistry reviews2013
Designing functional metalloproteins: from structural to catalytic metal sites.
Article in Coordination chemistry reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 125 citations in OpenAlex.
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- μ₃-Oxo nucleophile formation enables efficient SCommunications chemistry · 2026Article
- De Novo design of α-helical heme binding proteins capable of versatile cofactor ligation.Methods in enzymology · 2025Article
- Co(II) Substitution Enhances the Esterase Activity of a de Novo Designed Zn(II) Carbonic Anhydrase.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles.Chemical science · 2023Article
- Incorporation of a molybdenum atom in a Rubredoxin-type Centre of a de novo-designed αJournal of inorganic biochemistry · 2023Article
- Gold-iron oxide (Au/FeFrontiers in molecular biosciences · 2023Article
- Catalysis and Electron Transfer inChemical reviews · 2022Review
- Metal ion-regulated assembly of designed modular protein cages.Science advances · 2022Article
- Supramolecular Hybrids from Cyanometallate Complexes and Diblock Copolypeptide Amphiphiles in Water.Molecules (Basel, Switzerland) · 2022Article
- Autonomous Reaction Network Exploration in Homogeneous and Heterogeneous Catalysis.Topics in catalysis · 2022Article
- Protein Assembly by Design.Chemical reviews · 2021Review
- Unravelling the Structure of the Tetrahedral Metal-Binding Site in METP3 through an Experimental and Computational Approach.Molecules (Basel, Switzerland) · 2021Article
- Identifying metal binding amino acids based on backbone geometries as a tool for metalloprotein engineering.Protein science : a publication of the Protein Society · 2021Article
- The pH-Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial α-Helical Metalloprotein.Angewandte Chemie (International ed. in English) · 2021Article
- Protein-caged zinc porphyrin as a carbonic anhydrase mimic for carbon dioxide capture.Scientific reports · 2020Article
- Heteromeric three-stranded coiled coils designed using a Pb(II)(Cys)Nature chemistry · 2020Article
- Review
- Rational De Novo Design of a Cu Metalloenzyme for Superoxide Dismutation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Noncoded Amino Acids in de Novo Metalloprotein Design: Controlling Coordination Number and Catalysis.Accounts of chemical research · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metalloenzymes efficiently catalyze some of the most important and difficult reactions in nature. For many years, coordination chemists have effectively used small molecule models to understand these systems. More recently, protein design has been shown to be an effective approach for mimicking metal coordination environments. Since the first designed proteins were reported, much success has been seen for incorporating metal sites into proteins and attaining the desired coordination environment but until recently, this has been with a lack of significant catalytic activity. Now there are examples of designed metalloproteins that, although not yet reaching the activity of native enzymes, are considerably closer. In this review, we highlight work leading up to the design of a small metalloprotein containing two metal sites, one for structural stability (HgS
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.