ArticleAmerican journal of physiology. Lung cellular and molecular physiology2013
Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth.
Article in American journal of physiology. Lung cellular and molecular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- IPF AT2 cells are stuck in transition and biophysically dysfunctional.bioRxiv : the preprint server for biology · 2026Article
- Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Alveologenesis: What Governs Secondary Septa Formation.International journal of molecular sciences · 2021Review
- Erythropoietin inhalation enhances adult canine alveolar-capillary formation following pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.EBioMedicine · 2018Article
- Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units.Pediatric research · 2018Article
- A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor.PloS one · 2018Article
- Article
- Comparative analysis of the mechanical signals in lung development and compensatory growth.Cell and tissue research · 2017Review
- Lung Regeneration Therapy for Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2017Review
- Perfusion-related stimuli for compensatory lung growth following pneumonectomy.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Localization and stretch-dependence of lung elastase activity in development and compensatory growth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Mouse pneumonectomy model of compensatory lung growth.Journal of visualized experiments : JoVE · 2014Article
- Defining a stimuli-response relationship in compensatory lung growth following major resection.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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Authors and funding
5 authors.
Funding
Abstract
Surgical resection of pulmonary tissue exerts a proregenerative stretch stimulus in the remaining lung units. Whether this regeneration process reenacts part or whole of lung morphogenesis developmental program remains unclear. To address this question, we analyzed the stretch-induced regenerating lung transcriptome in mice after left pneumonectomy (PNX) in its developmental context. We created a C57BL/6 mice lung regeneration transcriptome time course at 3, 7, 14, 28, and 56 days post-PNX, profiling the cardiac and medial lobes and whole right lung. Prominent expression at days 3 and 7 of genes related to cell proliferation (Ccnb1, Bub1, and Cdk1), extracellular matrix (Col1a1, Eln, and Tnc), and proteases (Serpinb2 and Mmp9) indicated regenerative processes that tapered off after 56 days. We projected the post-PNX transcriptomic time course into the transcriptomic principal component space of the C57BL/6 mouse developing lungs time series from embryonic day 9.5 to postnatal day 56. All post-PNX samples were localized around the late postnatal stage of developing lungs. Shortly after PNX, the temporal trajectory of regenerating lobes and right lung reversed course relative to the developing lungs in a process reminiscent of dedifferentiation. This reversal was limited to the later postnatal stage of lung development. The post-PNX temporal trajectory then moves forward in lung development time close to its pre-PNX state after days 28 to 56 in a process resembling redevelopment. A plausible interpretation is that remaining pulmonary tissue reverts to a more primitive stage of development with higher potential for growth to generate tissue in proportion to the loss.
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