ArticleAmerican journal of physiology. Heart and circulatory physiology2013
Maximum shortening velocity of lymphatic muscle approaches that of striated muscle.
Article in American journal of physiology. Heart and circulatory physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Control of lymphatic pacemaking and pumping by mechanobiological signals.The Journal of physiology · 2025Article
- Mechanical feedback mechanisms in a multiscale sliding filament model of lymphatic muscle pumping.Applications in engineering science · 2025Article
- Overview of Lymphatic Muscle Cells in Development, Physiology, and Disease.Microcirculation (New York, N.Y. : 1994) · 2024Review
- A 1D model characterizing the role of spatiotemporal contraction distributions on lymph transport.Scientific reports · 2023Article
- Lymphatic Clearance and Pump Function.Cold Spring Harbor perspectives in medicine · 2023Review
- KAmerican journal of physiology. Cell physiology · 2022Review
- A multiscale sliding filament model of lymphatic muscle pumping.Biomechanics and modeling in mechanobiology · 2021Article
- Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels.The Journal of general physiology · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Mechanisms of Connexin-Related Lymphedema.Circulation research · 2018Article
- Differences in L-type CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Experimental Models Used to Assess Lymphatic Contractile Function.Lymphatic research and biology · 2017Review
- Article
- Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Mechanical forces and lymphatic transport.Microvascular research · 2014Review
- Itching for answers: how histamine relaxes lymphatic vessels.Microcirculation (New York, N.Y. : 1994) · 2014Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Lymphatic muscle (LM) is widely considered to be a type of vascular smooth muscle, even though LM cells uniquely express contractile proteins from both smooth muscle and cardiac muscle. We tested the hypothesis that LM exhibits an unloaded maximum shortening velocity (Vmax) intermediate between that of smooth muscle and cardiac muscle. Single lymphatic vessels were dissected from the rat mesentery, mounted in a servo-controlled wire myograph, and subjected to isotonic quick release protocols during spontaneous or agonist-evoked contractions. After maximal activation, isotonic quick releases were performed at both the peak and plateau phases of contraction. Vmax was 0.48 ± 0.04 lengths (L)/s at the peak: 2.3 times higher than that of mesenteric arteries and 11.4 times higher than mesenteric veins. In cannulated, pressurized lymphatic vessels, shortening velocity was determined from the maximal rate of constriction [rate of change in internal diameter (-dD/dt)] during spontaneous contractions at optimal preload and minimal afterload; peak -dD/dt exceeded that obtained during any of the isotonic quick release protocols (2.14 ± 0.30 L/s). Peak -dD/dt declined with pressure elevation or activation using substance P. Thus, isotonic methods yielded Vmax values for LM in the mid to high end (0.48 L/s) of those the recorded for phasic smooth muscle (0.05-0.5 L/s), whereas isobaric measurements yielded values (>2.0 L/s) that overlapped the midrange of values for cardiac muscle (0.6-3.3 L/s). Our results challenge the dogma that LM is classical vascular smooth muscle, and its unusually high Vmax is consistent with the expression of cardiac muscle contractile proteins in the lymphatic vessel wall.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.