ArticleEMBO molecular medicine2013
Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease.
Article in EMBO molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Urine-Derived Stem Cells: Challenges in Isolation, Biological Identity, and Therapeutic Potential in CKD-Associated Fibrosis.International journal of molecular sciences · 2026Review
- Co-induction of stromal and epithelial progenitors for renal regeneration.Innovation (Cambridge (Mass.)) · 2026Article
- Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate.The EMBO journal · 2025Article
- A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development.Innovation (Cambridge (Mass.)) · 2025Article
- A Novel Protocol for Culturing Polarized Proximal Tubular Epithelial Cells from Kidney Biopsies: Enhancing Platforms for Drug Excretion and Nephrotoxicity Studies.Journal of xenobiotics · 2025Article
- Development and intra-renal delivery of renal progenitor organoids for effective integration in vivo.Stem cells translational medicine · 2025Article
- Article
- OCT4 induces long-lived dedifferentiated kidney progenitors poised to redifferentiate in 3D kidney spheroids.Molecular therapy. Methods & clinical development · 2023Article
- Association between the prognostic nutritional index (PNI) and all-cause mortality in patients with chronic kidney disease.Renal failure · 2023Article
- Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model.Microvascular research · 2022Article
- Article
- Therapeutic role of uterine-derived stem cells in acute kidney injury.Stem cell research & therapy · 2022Article
- Identifying effective diagnostic biomarkers and immune infiltration features in chronic kidney disease by bioinformatics and validation.Frontiers in pharmacology · 2022Article
- Article
- Potential Strategies for Kidney Regeneration With Stem Cells: An Overview.Frontiers in cell and developmental biology · 2022Review
- Generation of Induced Nephron Progenitor-like Cells from Human Urine-Derived Cells.International journal of molecular sciences · 2021Article
- Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions.Journal of the American Society of Nephrology : JASN · 2021Article
- Review
- Human kidney clonal proliferation disclose lineage-restricted precursor characteristics.Scientific reports · 2020Article
- Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease.Stem cell research & therapy · 2020Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
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Abstract
Identification of tissue-specific renal stem/progenitor cells with nephrogenic potential is a critical step in developing cell-based therapies for renal disease. In the human kidney, stem/progenitor cells are induced into the nephrogenic pathway to form nephrons until the 34 week of gestation, and no equivalent cell types can be traced in the adult kidney. Human nephron progenitor cells (hNPCs) have yet to be isolated. Here we show that growth of human foetal kidneys in serum-free defined conditions and prospective isolation of NCAM1(+) cells selects for nephron lineage that includes the SIX2-positive cap mesenchyme cells identifying a mitotically active population with in vitro clonogenic and stem/progenitor properties. After transplantation in the chick embryo, these cells-but not differentiated counterparts-efficiently formed various nephron tubule types. hNPCs engrafted and integrated in diseased murine kidneys and treatment of renal failure in the 5/6 nephrectomy kidney injury model had beneficial effects on renal function halting disease progression. These findings constitute the first definition of an intrinsic nephron precursor population, with major potential for cell-based therapeutic strategies and modelling of kidney disease.
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