ReviewJournal of applied genetics2013
Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.
Review in Journal of applied genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 96 citations in OpenAlex.
- The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families.Journal of ovarian research · 2024Article
- Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints.Molecular ecology · 2024Article
- A Critical Functional Missense Mutation (T117M) in SheepAnimals : an open access journal from MDPI · 2024Article
- Genetic diversity and recent ancestry based on whole-genome sequencing of endangered Swedish cattle breeds.BMC genomics · 2024Article
- Signatures of selection in Angus and Hanwoo beef cattle using imputed whole genome sequence data.Frontiers in genetics · 2024Article
- Genetic characterization of cashmere goat (Frontiers in genetics · 2024Article
- Article
- Convergent changes in melanocortin receptor 1 gene are associated with black-headed coat color in sheep.Journal of animal science · 2023Article
- Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.International journal of molecular sciences · 2022Article
- Reversion of MRAP2 Protein Sequence Generates a Functional Novel Pharmacological Modulator for MC4R Signaling.Biology · 2022Article
- Identification of Candidate Genes for Pigmentation in Camels Using Genotyping-by-Sequencing.Animals : an open access journal from MDPI · 2022Article
- The Obesogenic Environment: Epigenetic Modifications in Placental Melanocortin 4 Receptor Gene Connected to Gestational Diabetes and Smoking.Frontiers in nutrition · 2022Article
- Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing.Frontiers in genetics · 2022Article
- Review
- A variant in the 3'-untranslated region of the MC2R gene decreases the risk of schizophrenia in a female Han Chinese population.The Journal of international medical research · 2021Article
- Two co-inherited novel SNPs in the MC4R gene related to live body weight and hormonal assays in Awassi and Arabi sheep breeds of Iraq.Veterinary medicine and science · 2021Article
- Melanocortin 5 receptor signaling pathway in health and disease.Cellular and molecular life sciences : CMLS · 2020Review
- Recent advances in amniote palaeocolour reconstruction and a framework for future research.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Genomic mapping identifies two genetic variants in the MC1R gene for coat colour variation in Chinese Tan sheep.PloS one · 2020Article
- Rapid identification and interpretation of gene-environment associations using the new R.SamBada landscape genomics pipeline.Molecular ecology resources · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The melanocortin receptor gene family consists of five single-exon members, which are located on autosomes. Three genes (MC2R, MC4R and MC5R) are syntenic in the human, mouse, cattle and dog genomes, while in the pig, the syntenic group comprises MC1R, MC2R and MC5R. Two genes (MC1R and MC4R) have been extensively studied due to their function in melanogenesis (MC1R) and energy control (MC4R). Conservative organisation of these genes in five mammalian species (human, mouse, cattle, pig and dog), in terms of the encoded amino acid sequence, is higher in the case of MC4R compared to MC1R. Polymorphisms of these two genes are responsible or associated with variation of pigmentation (MC1R) and adipose tissue deposition (MC4R). Polymorphic variants in MC1R, causing coat colour variation, were described in humans and domestic mammals (cattle, horse, pig, sheep, dog), as well as farm red and arctic foxes. The MC4R gene is very polymorphic in humans and it is well known that some variants cause monogenic obesity or significantly contribute to the development of polygenic obesity. Such relationships are not so evident in domestic mammals; however, at least one missense substitution (298Asp > Asn) in the porcine MC4R significantly contributes, at least in some breeds, to fat tissue accumulation, feed conversion ratio and daily weight gain. Knowledge on the phenotypic effects of polymorphisms of MC2R, MC3R and MC5R in domestic mammals is scarce, probably due to the small number of reports addressing these genes. Thus, further studies focused on these genes should be undertaken.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.