Evidence map›Paper›PMID 23996575›Full record

ArticleHead & neck2014

Head and neck squamous cell carcinoma of unknown primary: neck dissection and radiotherapy or definitive radiotherapy.

Candan Demiroz, Jeffrey M Vainshtein, Georgios V Koukourakis, Orit Gutfeld, Mark E Prince, Carol R Bradford, Gregory T Wolf, Scott McLean, Francis P Worden, Douglas B Chepeha and 2 more

Open access · greenAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Roles of Ki-67 and p16 as biomarkers for unknown primary head and neck squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 4 countries.

Candan Demiroz *Department of Radiation Oncology, Uludag University Faculty of Medicine, Bursa, Turkey; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Jeffrey M Vainshtein *Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Georgios V KoukourakisDepartment of Radiation Oncology, Saint Savvas Anticancer Institute of Athens, Greece; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Orit GutfeldDivision of Oncology, Institute of Radiation Therapy, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Mark E PrinceDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI.
Carol R BradfordDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI.
Scott McLeanDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI.
Francis P WordenDivision of Hematology Oncology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
Douglas B ChepehaDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI.
Matthew J SchipperDepartment of Biostatistics, University of Michigan, Ann Arbor, MI.
Jonathan B McHughDepartment of Pathology, University of Michigan, Ann Arbor, MI Avraham Eisbruch, MD, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
University of Michigan–Ann Arbor · USSt Savas Hospital · GRTel Aviv Sourasky Medical Center · IL

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOLF, GREGORY T · 2002 to 2013
$25.3M
NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA097248
6 · The paper itself

Abstract

backgroundManagement of head and neck carcinoma from unknown primary (HNCUP) remains controversial, with neck dissection and radiotherapy (RT) or definitive RT both commonly used. The purpose of this study was to characterize HNCUP and retrospectively compare outcomes for patients treated with neck dissection + RT versus definitive RT.

methodsFrom 1994 to 2009, 41 patients with HNCUP underwent either neck dissection + RT (n = 22) or definitive RT ± concurrent chemotherapy (n = 19) at our institution. Treatment outcomes were compared using Kaplan-Meier methods and log-rank test.

resultsThere were no differences between patients treated with neck dissection + RT and definitive RT in overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRFS), freedom from locoregional failure (FFLRG), or freedom from distant failure (FFDF). Among 17 patients who underwent neck dissection + RT for whom human papillomavirus (HPV) status could be determined, HPV(+) patients trended toward improved OS (p = .06) and PFS (p = .15).

conclusionNeck dissection and postoperative RT resulted in similar outcomes as definitive RT. The prognostic implications of HPV(+) nodes in HNCUP are similar to those in oropharyngeal primary cancers.

Indexed as

AdultAgedChi-Square DistributionCombined Modality TherapyDatabases, FactualDisease-Free SurvivalFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateMaleMiddle AgedNeck DissectionNeoplasm InvasivenessNeoplasm StagingNeoplasms, Unknown Primaryhuman papillomavirusneck dissectionradiation therapyunknown primary

Identifiers

PMID23996575
PMCPMC4241546
OpenAlexW1735371414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.