ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2013
The role of carbohydrates at the origin of homochirality in biosystems.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross-Disciplinary Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- On the Origin of Sugar Handedness: Facts, Hypotheses and Missing Links-A Review.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2022Review
- Article
- Magnetic circular dichroism in Archean atmosphere and asymmetric photolysis of biomolecules: enantiomeric excess of prebiotic sugar.Journal of biological physics · 2020Article
- The Limited Roles of Autocatalysis and Enantiomeric Cross-Inhibition in Achieving Homochirality in Dilute Systems.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2019Article
- Gas-phase sugar formation using hydroxymethylene as the reactive formaldehyde isomer.Nature chemistry · 2018Article
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Abstract
Pasteur has demonstrated that the chiral components in a racemic mixture can separate in homochiral crystals. But with a strong chiral discrimination the chiral components in a concentrated mixture can also phase separate into homochiral fluid domains, and the isomerization kinetics can then perform a symmetry breaking into one thermodynamical stable homochiral system. Glyceraldehyde has a sufficient chiral discrimination to perform such a symmetry breaking. The requirement of a high concentration of the chiral reactant(s) in an aqueous solution in order to perform and maintain homochirality; the appearance of phosphorylation of almost all carbohydrates in the central machinery of life; the basic ideas that the biochemistry and the glycolysis and gluconeogenesis contain the trace of the biochemical evolution, all point in the direction of that homochirality was obtained just after- or at a phosphorylation of the very first products of the formose reaction, at high concentrations of the reactants in phosphate rich compartments in submarine hydrothermal vents. A racemic solution of D,L-glyceraldehyde-3-phosphate could be the template for obtaining homochiral D-glyceraldehyde-3-phosphate(aq) as well as L-amino acids.
Indexed as
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23996458What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.