Evidence map›Paper›PMID 23996294›Full record

ArticleObesity surgery2014

Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans.

Ahmed Yousseif, Julian Emmanuel, Efthimia Karra, Queensta Millet, Mohamed Elkalaawy, Andrew D Jenkinson, Majid Hashemi, Marco Adamo, Nicholas Finer, Alberic G Fiennes and 2 more

2 registry-linked trialsOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 135 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 5 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03851874 nacompletednot on this map

A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2011 to 2014Enrolled28ConditionsMorbid ObesityArmsBariatric surgery
NCT04170010 unknown statusnot on this mapstarted 2019, after this paper: background citation

Postprandial Gut Hormone Responses and Meal-induced Thermogenesis After Non-surgical Long-term Weight Loss; Comparison With Surgically Treated Obese Individuals

TypeobservationalSponsorNational and Kapodistrian University of AthensRan2019 to 2023Enrolled45ConditionsMorbid Obesity
3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 5 syntheses or guidelines pooled it, 254 citations in OpenAlex.

  1. Pooled it
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  3. Methodological issues in assessing change in dietary intake and appetite following gastric bypass surgery: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  16. The role of the gut-brain axis in bariatric surgery.Current opinion in neurobiology · 2025
    Review
  17. The Enteric Neuronal Circuitry: A Key Ignored Player in Nutrient Sensing Along the Gut-Brain Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  18. Review
  19. Article
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ahmed YousseifCentre for Obesity Research Department of Medicine, University College London, Rayne Institute, 5, University Street, WC1E 6JJ, London, UK.
Julian Emmanuel
Efthimia Karra
Queensta Millet
Mohamed Elkalaawy
Andrew D Jenkinson
Majid Hashemi
Marco Adamo
Nicholas Finer
Alberic G Fiennes
Dominic J Withers
Rachel L Batterham
University College London · GBRoyal London Hospital · GBImperial College London · GBSpire St Anthony’s Hospital · GB

Funding

Medical Research Council G0601342Medical Research Council MC_U120097114
6 · The paper itself

Abstract

Laparoscopic Roux-en-Y gastric bypass (LRYGBP) reduces appetite and induces significant and sustainable weight loss. Circulating gut hormones changes engendered by LRYGBP are implicated in mediating these beneficial effects. Laparoscopic sleeve gastrectomy (LSG) is advocated as an alternative to LRYGBP, with comparable short-term weight loss and metabolic outcomes. LRYGBP and LSG are anatomically distinct procedures causing differential entero-endocrine cell nutrient exposure and thus potentially different gut hormone changes. Studies reporting the comparative effects of LRYGBP and LSG on appetite and circulating gut hormones are controversial, with no data to date on the effects of LSG on circulating peptide YY3-36 (PYY3-36) levels, the specific PYY anorectic isoform. In this study, we prospectively investigated appetite and gut hormone changes in response to LRYGBP and LSG in adiposity-matched non-diabetic patients. Anthropometric indices, leptin, fasted and nutrient-stimulated acyl-ghrelin, active glucagon-like peptide-1 (GLP-1), PYY3-36 levels and appetite were determined pre-operatively and at 6 and 12 weeks post-operatively in obese, non-diabetic females, with ten undergoing LRYGBP and eight adiposity-matched females undergoing LSG. LRYGBP and LSG comparably reduced adiposity. LSG decreased fasting and post-prandial plasma acyl-ghrelin compared to pre-surgery and to LRYGBP. Nutrient-stimulated PYY3-36 and active GLP-1 concentrations increased post-operatively in both groups. However, LRYGBP induced greater, more sustained PYY3-36 and active GLP-1 increments compared to LSG. LRYGBP suppressed fasting hunger compared to LSG. A similar increase in post-prandial fullness was observed post-surgery following both procedures. LRYGBP and LSG produced comparable enhanced satiety and weight loss. However, LSG and LRYGBP differentially altered gut hormone profiles.

Indexed as

AppetiteGastrectomyGastric BypassLaparoscopyAdolescentAdultBody Mass IndexFemaleGhrelinGlucagon-Like Peptide 1HumansMiddle AgedObesity, MorbidPeptide FragmentsPeptide YYProspective StudiesGhrelinGlucagon-Like Peptide 1Peptide FragmentsPeptide YYpeptide YY (3-36)

Identifiers

PMID23996294
PMCPMC3890046
OpenAlexW2088221687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.