Evidence map›Paper›PMID 23996287›Full record

Trial reportSocial cognitive and affective neuroscience2014

Preliminary evidence that sub-chronic citalopram triggers the re-evaluation of value in intimate partnerships.

Amy C Bilderbeck, Judi Wakeley, Beata R Godlewska, Francis McGlone, Tirril Harris, Phillip J Cowen, Robert D Rogers

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Effects of MDMA on attention to positive social cues and pleasantness of affective touch.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  2. Article
  3. Modulation of Social CognitionFrontiers in psychiatry · 2019
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amy C BilderbeckDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Judi WakeleyDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Beata R GodlewskaDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Francis McGloneDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Tirril HarrisDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Phillip J CowenDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS.
Robert D RogersDepartment of Psychiatry, Oxford University, Oxford, OX3 7JX, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, Institute of Psychiatry, King's College, London, England and School of Psychology, Bangor University, Adeilad Brigantia, Bangor, LL57 1AS r.rogers@bangor.ac.uk.
Liverpool John Moores University · GBUniversity of Oxford · GBBangor University · GB

Funding

Medical Research Council G0700410
6 · The paper itself

Abstract

Depression frequently involves disrupted inter-personal relationships, while treatment with serotonergic anti-depressants can interfere with libido and sexual function. However, little is known about how serotonin activity influences appraisals of intimate partnerships. Learning more could help to specify how serotonergic mechanisms mediate social isolation in psychiatric illness. Forty-four healthy heterosexual adults, currently in romantic relationships, received 8 days treatment with the selective serotonin re-uptake inhibitor citalopram (N = 21; 10 male) or placebo (N = 23; 12 male). Participants viewed photographs of unknown, heterosexual couples and made a series of judgements about their relationships. Participants also indicated the importance of relationship features in their own close partnerships, and close partnerships generally. Citalopram reduced the rated quality of couples' physical relationships and the importance attributed to physical and intimate aspects of participants' own relationships. In contrast, citalopram also enhanced the evaluated worth of mutual trust in relationships. Amongst males, citalopram was associated with judgements of reduced turbulence and bickering in others' relationships, and increased male dominance. These data constitute preliminary evidence that enhancing serotonin activity modulates cognitions about sexual activity as part of a re-appraisal of sources of value within close intimate relationships, enhancing the judged importance of longer-term benefits of trust and shared experiences.

Indexed as

Interpersonal RelationsAdultAnalysis of VarianceCitalopramDouble-Blind MethodFemaleHumansMalePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSexual BehaviorSurveys and QuestionnairesTrustVisual Analog ScaleYoung AdultCitalopramSelective Serotonin Reuptake Inhibitorsdepressionintimate relationshipsserotoninsocial isolationsocial judgements

Identifiers

PMID23996287
PMCPMC4158381
OpenAlexW2126201286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.