Evidence map›Paper›PMID 23996195›Full record

ReviewEuropean biophysics journal : EBJ2013

Helical membrane protein conformations and their environment.

Timothy A Cross, Dylan T Murray, Anthony Watts

Abstract readReview
In one paragraph

Review in European biophysics journal : EBJ, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Advances in native cell membrane nanoparticles system.Current opinion in structural biology · 2025
    Review
  2. Article
  3. Review
  4. Membrane mimetic-dependence of GPCR energy landscapes.Structure (London, England : 1993) · 2024
    Article
  5. Article
  6. Membrane Mimetic-Dependence of GPCR Energy Landscapes.bioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Timothy A CrossDepartment of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306, USA, cross@magnet.fsu.edu.
Dylan T Murray
Anthony Watts

Funding

Target IdentificationP01AI074805 · NIAID · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 2009 to 2013
$8.7M
DYNAMIC AND STRUCTURAL ELUCIDATION OF GRAMICIDIN A'R01AI023007 · NIAID · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 1987 to 2014
$5.1M
Four Mtb Membrane Proteins: Structure and FunctionR01AI073891 · NIAID · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 2008 to 2012
$2.0M
Medical Research CouncilNIAID NIH HHS AI 023007NIAID NIH HHS AI 073891NIAID NIH HHS AI 074805NIAID NIH HHS P01 AI074805NIAID NIH HHS R01 AI023007NIAID NIH HHS R01 AI073891
6 · The paper itself

Abstract

Evidence that membrane proteins respond conformationally and functionally to their environment is growing. Structural models, by necessity, have been characterized in preparations where the protein has been removed from its native environment. Different structural methods have used various membrane mimetics that have recently included lipid bilayers as a more native-like environment. Structural tools applied to lipid bilayer-embedded integral proteins are informing us about important generic characteristics of how membrane proteins respond to the lipid environment as compared with their response to other nonlipid environments. Here, we review the current status of the field, with specific reference to observations of some well-studied α-helical membrane proteins, as a starting point to aid the development of possible generic principles for model refinement.

Indexed as

Cell MembraneMembrane ProteinsMembranes, ArtificialProtein Structure, SecondaryProtein Structure, TertiaryMembrane ProteinsMembranes, Artificial

Identifiers

PMID23996195
PMCPMC3818118

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.