ArticleJournal of cellular physiology2014
Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.
Article in Journal of cellular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Multi-Channel Cellytics for Rapid and Cost-Effective Monitoring of Leukocyte Activation.Biosensors · 2025Article
- Cellular context alters EGF-induced ERK dynamics and reveals potential crosstalk with GDF-15.Biomicrofluidics · 2022Article
- Insights intoMaterials (Basel, Switzerland) · 2020Article
- Ras Suppressor-1 (RSU1) in Cancer Cell Metastasis: A Tale of a Tumor Suppressor.International journal of molecular sciences · 2020Review
- Estradiol-17β-Induced Changes in the Porcine Endometrial Transcriptome In Vivo.International journal of molecular sciences · 2020Article
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion.Cancers · 2019Article
- Mechanically-induced GDF15 Secretion by Periodontal Ligament Fibroblasts Regulates Osteogenic Transcription.Scientific reports · 2019Article
- Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells.Scientific reports · 2019Article
- Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15).International journal of molecular sciences · 2019Article
- Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression.Frontiers in oncology · 2019Article
- Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration.Annals of biomedical engineering · 2018Article
- Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.EBioMedicine · 2018Article
- Image-Based Tracking of Heterogeneous Single-Cell Phenotypes.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Tracking the tumor invasion front using long-term fluidic tumoroid culture.Scientific reports · 2017Article
- Biophysical and biomolecular determination of cellular age in humans.Nature biomedical engineering · 2017Article
- Mechanotransduction-Induced Reversible Phenotypic Switching in Prostate Cancer Cells.Biophysical journal · 2017Article
- Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells.Investigative ophthalmology & visual science · 2016Article
- Single cell dynamic phenotyping.Scientific reports · 2016Article
- Can Serum Gdf-15 be Associated with Functional Iron Deficiency in Hemodialysis Patients?Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cancer cells typically demonstrate altered morphology during the various stages of disease progression as well as metastasis. While much is known about how altered cell morphology in cancer is a result of genetic regulation, less is known about how changes in cell morphology affect cell function by influencing gene expression. In this study, we altered cell morphology in different types of cancer cells by disrupting the actin cytoskeleton or by modulating attachment and observed a rapid up-regulation of growth differentiation factor 15 (GDF15), a member of the transforming growth factor-beta (TGF-β) super-family. Strikingly, this up-regulation was sustained as long as the cell morphology remained altered but was reversed upon allowing cell morphology to return to its typical configuration. The potential significance of these findings was examined in vivo using a mouse model: a small number of cancer cells grown in diffusion chambers that altered morphology increased mouse serum GDF15. Taken together, we propose that during the process of metastasis, cancer cells experience changes in cell morphology, resulting in the increased production and secretion of GDF15 into the surrounding environment. This indicates a possible relationship between serum GDF15 levels and circulating tumor cells may exist. Further investigation into the exact nature of this relationship is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.