SynthesisEuropean journal of pediatrics2014
Early biomarkers as predictors for bronchopulmonary dysplasia in preterm infants: a systematic review.
Synthesis in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Role of connexin 43 in hyperoxia-induced bronchopulmonary dysplasia and associated pulmonary hypertension.PloS one · 2026Article
- Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants.Sensors (Basel, Switzerland) · 2024Article
- Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants.Critical care research and practice · 2024Article
- Relationship between hematological parameters and bronchopulmonary dysplasia in premature infants.The Journal of international medical research · 2023Article
- Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia.Pediatric research · 2023Article
- Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants.Frontiers in pediatrics · 2023Article
- Precision Medicine in Neonates: Future Perspectives for the Lung.Frontiers in pediatrics · 2020Review
- Anti-placental growth factor antibody ameliorates hyperoxia-mediated impairment of lung development in neonatal rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Bronchopulmonary dysplasia.Nature reviews. Disease primers · 2019Review
- Serum neurotrophins at birth correlate with respiratory and neurodevelopmental outcomes of premature infants.Pediatric pulmonology · 2019Article
- High Neutrophil-to-Lymphocyte Ratio Is an Early Predictor of Bronchopulmonary Dysplasia.Frontiers in pediatrics · 2019Article
- Bronchopulmonary Dysplasia: Comparison Between the Two Most Used Diagnostic Criteria.Frontiers in pediatrics · 2018Article
- Histologic Chorioamnionitis, Amniotic Fluid Interleukin 6, Krebs von den Lungen 6, and Transforming Growth Factor βJapanese clinical medicine · 2017Article
- Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development.Molecular and cellular pediatrics · 2016Review
- Inflammatory and oxidative stress airway markers in premature newborns of hypertensive mothers.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Observational
- Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant.Frontiers in pediatrics · 2016Review
- A comparison of KL-6 and Clara cell protein as markers for predicting bronchopulmonary dysplasia in preterm infants.Disease markers · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBronchopulmonary dysplasia (BPD) is usually diagnosed in preterm infants at least 28 days after birth. Great interest lies in the potential to identify biomarkers that predict development of the disease and future neurodevelopmental outcomes. We have reviewed the existing literature on early biomarkers as predictors for BPD in preterm infants.
methodsTwo reviewers independently searched the databases of PubMed, EMBASE, and Google Scholar for studies pertaining to biomarkers for BPD. Studies were assessed using Quality Assessment of Diagnostic Accuracy Studies criteria.
resultsWe identified 46 relevant articles that are summarized in the review. These studies assessed over 30 potential biomarkers. Sensitivity and specificity of biomarkers were reported or could be calculated for only 16 articles, and ranged from 0 to 100 %. Based on the nine highest quality studies, serum KL-6, CC16, neutrophil gelatinase-associated lipocalin, and end-tidal carbon monoxide (etCO) perform extremely well in predicting the early diagnosis of established BPD, highlighting these biomarkers as promising candidates for future research.
conclusionsPublished data from studies on serum biomarkers and etCO suggest that biomarkers may have great potential to predict the subsequent BPD and neurodevelopmental outcomes. These biomarkers need validation in larger studies, and the generalizability of biomarkers for predicting BPD, as well as the neurodevelopmental outcomes, needs to be further explored.
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