ArticleApplied and environmental microbiology2013
Bifidobacterium animalis subsp. lactis ATCC 27673 is a genomically unique strain within its conserved subspecies.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comparative genome analysis of microbial strains marketed for probiotic interventions: an extension of the Integrated Probiotic Database.Microbiome research reports · 2024Article
- Review and Perspectives onMicroorganisms · 2023Review
- Effects of Bacterial Lysates and Metabolites on Collagen Homeostasis in TNF-α-Challenged Human Dermal Fibroblasts.Microorganisms · 2023Article
- Genomic Island-Mediated Horizontal Transfer of the Erythromycin Resistance GeneApplied and environmental microbiology · 2022Article
- Genome-Wide Assessment of Stress-Associated Genes in Bifidobacteria.Applied and environmental microbiology · 2022Article
- Bifidobacteria Strain Typing by Fourier Transform Infrared Spectroscopy.Frontiers in microbiology · 2021Article
- Editorial: Authenticity of Probiotic Foods and Dietary Supplements.Frontiers in microbiology · 2021Article
- The Tetracycline Resistance Gene,Frontiers in microbiology · 2021Article
- Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation.Nutrients · 2020Article
- Dissecting the Evolutionary Development of the SpeciesApplied and environmental microbiology · 2019Article
- Transcriptional and Functional Analysis of Bifidobacterium animalis subsp. lactis Exposure to Tetracycline.Applied and environmental microbiology · 2018Article
- Article
- Genotyping by PCR and High-Throughput Sequencing of Commercial Probiotic Products Reveals Composition Biases.Frontiers in microbiology · 2016Article
- A single mutation in the gene responsible for the mucoid phenotype of Bifidobacterium animalis subsp. lactis confers surface and functional characteristics.Applied and environmental microbiology · 2015Article
- A Phytase-Based Reporter System for Identification of Functional Secretion Signals in Bifidobacteria.PloS one · 2015Article
- Short- and long-term dynamics in the intestinal microbiota following ingestion of Bifidobacterium animalis subsp. lactis GCL2505.Bioscience of microbiota, food and health · 2015Article
- The domestication of the probiotic bacterium Lactobacillus acidophilus.Scientific reports · 2014Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Many strains of Bifidobacterium animalis subsp. lactis are considered health-promoting probiotic microorganisms and are commonly formulated into fermented dairy foods. Analyses of previously sequenced genomes of B. animalis subsp. lactis have revealed little genetic diversity, suggesting that it is a monomorphic subspecies. However, during a multilocus sequence typing survey of Bifidobacterium, it was revealed that B. animalis subsp. lactis ATCC 27673 gave a profile distinct from that of the other strains of the subspecies. As part of an ongoing study designed to understand the genetic diversity of this subspecies, the genome of this strain was sequenced and compared to other sequenced genomes of B. animalis subsp. lactis and B. animalis subsp. animalis. The complete genome of ATCC 27673 was 1,963,012 bp, contained 1,616 genes and 4 rRNA operons, and had a G+C content of 61.55%. Comparative analyses revealed that the genome of ATCC 27673 contained six distinct genomic islands encoding 83 open reading frames not found in other strains of the same subspecies. In four islands, either phage or mobile genetic elements were identified. In island 6, a novel clustered regularly interspaced short palindromic repeat (CRISPR) locus which contained 81 unique spacers was identified. This type I-E CRISPR-cas system differs from the type I-C systems previously identified in this subspecies, representing the first identification of a different system in B. animalis subsp. lactis. This study revealed that ATCC 27673 is a strain of B. animalis subsp. lactis with novel genetic content and suggests that the lack of genetic variability observed is likely due to the repeated sequencing of a limited number of widely distributed commercial strains.
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