Evidence map›Paper›PMID 23995813›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014

Strength and endurance training in the treatment of lung cancer patients in stages IIIA/IIIB/IV.

C C Henke, J Cabri, L Fricke, W Pankow, G Kandilakis, P C Feyer, M de Wit

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02978521 (Effect of a Pulmonary Rehabilitation Program on Skeletal Muscle Mass, Pulmonary Function, Inflammatory Response and Overall Survival on Patients Diagnosed With Non-small-cell Advanced Cancer), which is not on this map. Cited by 97 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 27 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02978521 narecruitingnot on this mapstarted 2016, after this paper: background citation

Effect of a Pulmonary Rehabilitation Program on Skeletal Muscle Mass, Pulmonary Function, Inflammatory Response and Overall Survival on Patients Diagnosed With Non-small-cell Advanced Cancer

TypeinterventionalSponsorInstituto Nacional de Cancerologia de MexicoRan2016 to 2027Enrolled94ConditionsPulmonary Rehabilitation, Sarcopenia, Quality of LifeArmsPulmonary rehabilitation
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 27 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
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  3. Nonpharmacological dyspnoea-relief strategies in lung cancer: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  4. Effects of exercise on people living with advanced lung cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  8. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  9. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  12. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  14. Effect of exercise interventions in adults with cancer receiving palliative care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  15. Is physical activity effective against cancer-related fatigue in lung cancer patients? An umbrella review of systematic reviews and meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C C HenkeDepartment of Internal Medicine, Hematology and Oncology, Vivantes Clinic Neukoelln, Rudower Strasse 48, 12351, Berlin, Germany.
J Cabri
L Fricke
W Pankow
G Kandilakis
P C Feyer
M de Wit
Vivantes Klinikum · DENorwegian School of Sport Sciences · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis randomized controlled trial tested the effects of a specially designed strength and endurance training on the independence and quality of life in lung cancer patients in stages IIIA/IIIB/IV during palliative chemotherapy.

methodsBetween August 2010 and December 2011, 46 patients were randomized into two groups receiving either conventional physiotherapy or special physiotherapeutic training. The Barthel Index served as primary endpoint. The secondary endpoints were the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ C-30/LC-13) questionnaire, the 6-Minute Walk Test (6MWT), stair walking, the Modified Borg Scale, and muscle strength. Nonparametrical data were analyzed with the Wilcoxon and Mann-Whitney U test. For parametric, data student t tests were used. A p value of ≤.05 was accepted.

resultsTwenty-nine patients completed the trial (Intervention group (IG), n = 18; control group (CG), n = 11). Significant differences were detectable in the Barthel Index (IGmean = 92.08; CGmean = 81.67; p = .041), in single scores of the EORTC QLQ C-30/LC-13 questionnaire (physical functioning, p = .025; hemoptysis, p = .019; pain in arms or shoulder, p = .048; peripheral neuropathy, p = .050; cognitive functioning, p = .050), in the 6MWT, stair walking, strength capacity, and in the patient's dyspnoea perception during submaximal walking activities (IG > CG).

conclusionAccording to these findings, lung cancer patients should receive enhanced physical activity intervention during palliative chemotherapy.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsExerciseExercise TherapyFemaleHumansLung NeoplasmsMaleMiddle AgedMuscle StrengthNeoplasm StagingOrganoplatinum CompoundsPhysical EnduranceProspective StudiesQuality of LifeSurveys and QuestionnairesOrganoplatinum Compounds

Identifiers

PMID23995813
OpenAlexW2009833418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.