ArticleCalcified tissue international2013
(18)F-fluoride positron emission tomography measurements of regional bone formation in hemodialysis patients with suspected adynamic bone disease.
Article in Calcified tissue international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Validation of quantitative [Annals of nuclear medicine · 2025Pooled it
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- PET/CT imaging of bone disorders in dysparathyroidism: a comprehensive review.Frontiers in nuclear medicine · 2025Review
- Imaging bone turnover assessment through volumetric density-adjusted standardized uptake value using quantitative bone SPECT/CT in osteoporosis.EJNMMI research · 2024Article
- Mixed uremic osteodystrophy: an ill-described common bone pathology in patients with chronic kidney disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Review
- Bone Turnover in Patients with Chronic Kidney Disease Stage 5D and Healthy Controls - a Quantitative [Molecular imaging and biology · 2023Article
- A systematic evaluation of five different image-derived input functions for the clinical implementation ofFrontiers in nuclear medicine · 2023Article
- Utility of a simplified [Frontiers in endocrinology · 2023Review
- Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet.International journal of molecular sciences · 2022Article
- Alkaline Phosphatase: An Old Friend as Treatment Target for Cardiovascular and Mineral Bone Disorders in Chronic Kidney Disease.Nutrients · 2022Review
- Association between bone mineral metabolism and vascular calcification in end-stage renal disease.BMC nephrology · 2022Article
- Bone Histomorphometry andCalcified tissue international · 2021Article
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- Association of Regional Bone Synthetic Activities of Vertebral Corners and Vertebral Bodies Quantified UsingJournal of clinical medicine · 2020Article
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- The influence of CT and dual-energy X-ray absorptiometry (DXA) bone density on quantitative [Quantitative imaging in medicine and surgery · 2019Article
- Functional and Hybrid Imaging of Bone Metastases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Review
- Site specific measurements of bone formation using [Quantitative imaging in medicine and surgery · 2018Review
- Biomarkers Predicting Bone Turnover in the Setting of CKD.Current osteoporosis reports · 2017Review
- Teriparatide for osteoporosis: importance of the full course.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
(18)F-fluoride positron emission tomography ((18)F-PET) allows the assessment of regional bone formation and could have a role in the diagnosis of adynamic bone disease (ABD) in patients with chronic kidney disease (CKD). The purpose of this study was to examine bone formation at multiple sites of the skeleton in hemodialysis patients (CKD5D) and assess the correlation with bone biopsy. Seven CKD5D patients with suspected ABD and 12 osteoporotic postmenopausal women underwent an (18)F-PET scan, and bone plasma clearance, K i, was measured at ten skeletal regions of interest (ROI). Fifteen subjects had a transiliac bone biopsy following double tetracycline labeling. Two CKD5D patients had ABD confirmed by biopsy. There was significant heterogeneity in K i between skeletal sites, ranging from 0.008 at the forearm to 0.028 mL/min/mL at the spine in the CKD5D group. There were no significant differences in K i between the two study groups or between the two subjects with ABD and the other CKD5D subjects at any skeletal ROI. Five biopsies from the CKD5D patients had single tetracycline labels only, including the two with ABD. Using an imputed value of 0.3 μm/day for mineral apposition rate (MAR) for biopsies with single labels, no significant correlations were observed between lumbar spine K i corrected for BMAD (K i/BMAD) and bone formation rate (BFR/BS), or MAR. When biopsies with single labels were excluded, a significant correlation was observed between K i/BMAD and MAR (r = 0.81, p = 0.008) but not BFR/BS. Further studies are required to establish the sensitivity of (18)F-PET as a diagnostic tool for identifying CKD patients with ABD.
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