ArticlePsychopharmacology2014
Modulation of 5-HT7 receptor: effect on object recognition performances in mice.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease.International journal of molecular sciences · 2020Review
- The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology.Molecular neurobiology · 2019Article
- Search for a 5-CT alternative.MedChemComm · 2018Article
- HBK-14 and HBK-15 with antidepressant-like and/or memory-enhancing properties increase serotonin levels in the hippocampus after chronic treatment in mice.Metabolic brain disease · 2017Article
- Hippocampal 5-HT7 receptors signal phosphorylation of the GluA1 subunit to facilitate AMPA receptor mediated-neurotransmission in vitro and in vivo.British journal of pharmacology · 2016Article
- Targeting the Serotonin 5-HT7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date.CNS drugs · 2015Review
- 5-HT7 receptor activation: procognitive and antiamnesic effects.Psychopharmacology · 2015Article
- Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist.Psychopharmacology · 2015Article
- Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.Frontiers in behavioral neuroscience · 2015Article
- Serotonin, neural markers, and memory.Frontiers in pharmacology · 2015Review
- Editorial: Further Understanding of Serotonin 7 Receptors' Neuro-psycho-pharmacology.Frontiers in behavioral neuroscience · 2015Article
- Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders.CNS neuroscience & therapeutics · 2014Review
- The serotonin receptor 7 and the structural plasticity of brain circuits.Frontiers in behavioral neuroscience · 2014Review
- 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders.Frontiers in cellular neuroscience · 2014Review
- 5-HT7 receptor stimulation and blockade: a therapeutic paradox about memory formation and amnesia.Frontiers in behavioral neuroscience · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryptamine (5-CT, a 5-HT1A/1B/1D/7R agonist) and/or SB-269970 (a selective 5-HT7R antagonist) immediately after the acquisition session of the novel object recognition test. MATERIALS AND
methodsThe object recognition test was performed in order to assess the effects of modulation of 5-HT7R during consolidation phase on episodic-like memory performances in mice. A protocol including 3 days of familiarisation to the apparatus has been realised in order to decrease the effect of novelty-induced arousal.
resultsWith a 2-h delay, SB-269970 (3 and 10 mg/kg, administered subcutaneously) impaired the discrimination of the novel object. With a 4-h delay, while control mice were not able to discriminate the novel object, mice treated with 5-CT (1 mg/kg) showed a significant discrimination. This promnesic effect with a long delay is effectively mediated by 5-HT7R activation since it was blocked by SB-269970 (10 mg/kg), but not by WAY-100135 (10 mg/kg) or by GR-127935 (10 mg/kg).
conclusionThese data suggest that 5-HT7R tonically modulates cognitive processes involved in consolidation performances in object recognition. Therefore, 5-HT7R could be a promising target to treat memory dysfunctions (especially episodically related deficits) related to normal or pathological ageing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.