Trial reportPsychopharmacology2014
Monoaminergic modulation of behavioural and electrophysiological indices of error processing.
Trial report in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others.Psychopharmacology · 2024Trial
- Pharmacological Manipulations of Physiological Arousal and Sleep-Like Slow Waves Modulate Sustained Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Trial
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- Electrophysiological correlates of oxytocin-induced enhancement of social performance monitoring.Social cognitive and affective neuroscience · 2017Trial
- Event-related potentials reflect impaired temporal interval learning following haloperidol administration.Psychopharmacology · 2017Trial
- Serotonin reuptake inhibitors and serotonin transporter genotype modulate performance monitoring functions but not their electrophysiological correlates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Trial
- Clustering Cortical Rhythms: Monoaminergic Signatures in Time-Frequency EEG Dynamics.Biomedicines · 2025Article
- Behavioral and neurophysiological signatures of cognitive control in humans and rats.The international journal of neuropsychopharmacology · 2024Article
- Pharmacological Elevation of Catecholamine Levels Improves Perceptual Decisions, But Not Metacognitive Insight.eNeuro · 2024Article
- Neurophysiological error processing and addiction self-awareness correlates of reduced insight in cannabis use disorder.Addiction (Abingdon, England) · 2023Article
- Dopaminergic and noradrenergic manipulation of anticipatory reward and probability event-related potentials.Psychopharmacology · 2020Article
- Processing of performance errors predicts memory formation: Enhanced feedback-related negativities for corrected versus repeated errors in an associative learning paradigm.The European journal of neuroscience · 2020Article
- Trial-by-trial source-resolved EEG responses to gait task challenges predict subsequent step adaptation.NeuroImage · 2019Article
- Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.Frontiers in psychiatry · 2019Article
- Dopaminergic modulation of performance monitoring in Parkinson's disease: An event-related potential study.Scientific reports · 2017Article
- Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus.Neurochemical research · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleError processing is a critical executive function that is impaired in a large number of clinical populations. Although the neural underpinnings of this function have been investigated for decades and critical error-related components in the human electroencephalogram (EEG), such as the error-related negativity (ERN) and the error positivity (Pe), have been characterised, our understanding of the relative contributions of key neurotransmitters to the generation of these components remains limited.
objectivesThe current study sought to determine the effects of pharmacological manipulation of the dopamine, noradrenaline and serotonin neurotransmitter systems on key behavioural and event-related potential correlates of error processing.
methodsA randomised, double-blinded, placebo-controlled, crossover design was employed. Monoamine levels were manipulated using the clinically relevant drugs methylphenidate, atomoxetine and citalopram, in comparison to placebo. Under each of the four drug conditions, participants underwent EEG recording while performing a flanker task.
resultsOnly methylphenidate produced significant improvement in performance accuracy, which was without concomitant slowing of reaction time. Methylphenidate also increased the amplitude of an early electrophysiological index of error processing, the ERN. Citalopram increased the amplitude of the correct-response negativity, another component associated with response processing.
conclusionsThe effects of methylphenidate in this study are consistent with theoretical accounts positing catecholamine modulation of error monitoring. Our data suggest that enhancing catecholamine function has the potential to remediate the error-monitoring deficits that are seen in a wide range of psychiatric conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.