Evidence map›Paper›PMID 23995130›Full record

ReviewCurrent opinion in critical care2013

Novelties in pharmacological management of cardiopulmonary resuscitation.

Jason A Bartos, Demetris Yannopoulos

Abstract readReview
In one paragraph

Review in Current opinion in critical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jason A BartosCardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Demetris Yannopoulos
Minneapolis VA Medical Center · USUniversity of Minnesota · US

Funding

Reperfusion Injury Protection Strategies During Basic Life SupportR01HL123227 · NHLBI · UNIVERSITY OF MINNESOTA · PI YANNOPOULOS, DEMETRIS · 2013 to 2017
$5.1M
Sodium nitroprusside and mechanical CPR adjuncts for cardio-cerebral resuscitatioR01HL108926 · NHLBI · UNIVERSITY OF MINNESOTA · PI YANNOPOULOS, DEMETRIS · 2011 to 2015
$2.6M
Reperfusion Injury Protection During Cardiac Arrest: A Novel CPR MethodR43HL115937 · NHLBI · RESQSYSTEMS, INC. · PI LURIE, KEITH, YANNOPOULOS, DEMETRIS · 2012 to 2012
$370k
Novel bundled mechanical and pharmacological CPR platformR43HL110517 · NHLBI · RESQSYSTEMS, INC. · PI METZGER, ANJA KOHLER · 2012 to 2012
$257k
Non-invasive Extra-Corporeal Circulator for Prolonged ResuscitationR43HL097479 · NHLBI · ADVANCED CIRCULATORY SYSTEMS, INC. · PI LURIE, KEITH G · 2009 to 2009
$195k
NHLBI NIH HHS 1R43HL110517-01A1NHLBI NIH HHS R01 HL108926NHLBI NIH HHS R01 HL108926-02NHLBI NIH HHS R01 HL123227NHLBI NIH HHS R43 HL097479NHLBI NIH HHS R43 HL097479-01NHLBI NIH HHS R43 HL110517NHLBI NIH HHS R43 HL115937NHLBI NIH HHS R43HL 115937-01
6 · The paper itself

Abstract

purpose of reviewThe ultimate goal of cardiopulmonary resuscitation is long-term neurologically intact survival. Despite numerous well-designed studies, the medications currently used in advanced cardiac life support have not demonstrated success in this regard. This review describes the novel therapeutics under investigation to improve functional recovery and survival. RECENT

findingsWhereas current medications focus on achieving return of spontaneous circulation and improved hemodynamics, novel therapies currently in development are focused on improving cellular survival and function by preventing metabolic derangement, protecting mitochondria, and preventing cell death caused by cardiac arrest. Improved cardiac and neurologic function and survival benefits have been observed using animal models of cardiopulmonary arrest. SUMMARY: Although substantial data have shown benefits using robust animal models, further human studies are necessary to investigate the potential long-term benefits of these therapies.

Indexed as

Adrenergic beta-AntagonistsAnalgesics, OpioidAnesthetics, InhalationAnimalsAnti-Arrhythmia AgentsCardiopulmonary ResuscitationCell SurvivalHeart ArrestHemodynamicsHumansRecovery of FunctionVasoconstrictor AgentsVasodilator AgentsAdrenergic beta-AntagonistsAnalgesics, OpioidAnesthetics, InhalationAnti-Arrhythmia AgentsVasoconstrictor AgentsVasodilator Agents

Identifiers

PMID23995130
PMCPMC4057183
OpenAlexW2036711839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.