Evidence map›Paper›PMID 23994708›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2013

Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen.

Cheryl E Ainslie-Waldman, Scott W Simpkins, Pramod Upadhyaya, Steven G Carmella, Stephen S Hecht, Sabrina P Trudo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Urinary 3,3'-diindolylmethane: a biomarker of glucobrassicin exposure and indole-3-carbinol uptake in humans.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cheryl E Ainslie-WaldmanDepartment of Food Science and Nutrition, University of Minnesota, 1334 Eckles Ave., St. Paul, MN 55108, USA; Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd St. S, Minneapolis, MN 55455, USA.
Scott W Simpkins
Pramod Upadhyaya
Steven G Carmella
Stephen S Hecht
Sabrina P Trudo

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Training Program in Nutrition and CancerT32CA132670 · NCI · UNIVERSITY OF MINNESOTA · PI ANDERSON, KRISTIN ELLEN · 2009 to 2013
$1.6M
Development of a Biomarker for Dietary FuranocoumarinsK07CA128952 · NCI · UNIVERSITY OF MINNESOTA · PI TRUDO, SABRINA · 2009 to 2013
$735k
NCI NIH HHS 5K07CA128952-02NCI NIH HHS K07 CA128952NCI NIH HHS P30 CA077598NCI NIH HHS P30 CA77598NCI NIH HHS T32 CA132670NCI NIH HHS T32CA132670
6 · The paper itself

Abstract

Bioactive compounds from plant foods are intensely investigated for effects on disease prevention. β-Glucuronidase/arylsulfatase from Helix pomatia (snail) is commonly used when quantifying exposure to metabolized dietary components. However, we describe here the contamination of multiple formulations of this enzyme preparation with 3,3'-diindolylmethane (DIM), 8-methoxypsoralen (8-MOP), and 5-methoxypsoralen (5-MOP), bioactives from cruciferous and apiaceous vegetables under investigation as putative cancer chemopreventive agents. We identified an Escherichia coli preparation of β-glucuronidase as free from contamination with any of the compounds tested. These results demonstrate the importance of selecting appropriate enzyme preparations when quantifying naturally occurring, trace level compounds in biological fluids.

Indexed as

Drug Contamination5-MethoxypsoralenAnimalsArylsulfatasesEscherichia coliGlucuronidaseHelix, SnailsIndolesMethoxsalenRecombinant Proteins3,3'-diindolylmethane5-MethoxypsoralenArylsulfatasesGlucuronidaseIndolesMethoxsalenRecombinant Proteins3,3′-diindolylmethane3,3′-Diindolylmethane5-methoxypsoralen5-Methoxypsoralen5-MOP8-methoxypsoralen8-Methoxypsoralen8-MOPCYPcytochrome P450Deconjugation enzymesDietary chemopreventionDIMHelix pomatiaI3Cindole-3-carbinollimit of quantitationLOQNDnot detectedUDP-glucuronosyltransferaseUGT

Identifiers

PMID23994708
PMCPMC3842406

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.