ArticleNeuroscience2013
Sex-dependent roles of prolactin and prolactin receptor in postoperative pain and hyperalgesia in mice.
Article in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Prolactin and pain of endometriosis.Pharmacology & therapeutics · 2023Pooled it
- Peri-adolescent ethanol exposure differentially affects mechanical and thermal sensitivity in rats.The journal of pain · 2026Article
- Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females.Frontiers in aging neuroscience · 2026Article
- Prolactin-induced sensitization of trigeminal nociceptors promotes migraine co-morbidity in endometriosis.Cephalalgia : an international journal of headache · 2025Article
- Degenerative and regenerative peripheral processes are associated with persistent painful chemotherapy-induced neuropathies in males and females.Scientific reports · 2024Article
- Endorphins, Sexuality, and Reproduction.Advances in neurobiology · 2024Article
- Retrospective analysis on the efficacy of epidural labor analgesia on early breast feeding after vaginal delivery.BMC anesthesiology · 2023Article
- Macrophages and microglia in inflammation and neuroinflammation underlying different pain states.Medical review (2021) · 2023Article
- Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury.Neural regeneration research · 2023Article
- Prolactin receptor signaling induces acquisition of chemoresistance and reduces clonogenicity in acute myeloid leukemia.Cancer cell international · 2023Article
- Prolactin and oxytocin: potential targets for migraine treatment.The journal of headache and pain · 2023Review
- Unveiling the Pathogenesis of Adenomyosis through Animal Models.Journal of clinical medicine · 2022Review
- A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sex Differences in Nociceptor Translatomes Contribute to Divergent Prostaglandin Signaling in Male and Female Mice.Biological psychiatry · 2022Article
- Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine.Headache · 2022Article
- A link between migraine and prolactin: the way forward.Future science OA · 2021Review
- Pituitary hormones are specifically expressed in trigeminal sensory neurons and contribute to pain responses in the trigeminal system.Scientific reports · 2021Article
- Comparison of Nociceptive Effects of Buprenorphine, Firocoxib, and Meloxicam in a Plantar Incision Model in Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones.Endocrinology · 2021Review
- Meningeal CGRP-Prolactin Interaction Evokes Female-Specific Migraine Behavior.Annals of neurology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Although surgical trauma activates the anterior pituitary gland and elicits an increase in prolactin (PRL) serum levels that can modulate nociceptive responses, the role of PRL and the PRL-receptor (PRL-R) in thermal and mechanical hyperalgesia in postoperative pain is unknown. Acute postoperative pain condition was generated with the use of the hindpaw plantar incision model. Results showed endogenous PRL levels were significantly increased in serum, operated hindpaw and spinal cords of male and female rats 24h after incision. These alterations were especially pronounced in females. We then examined the role of the PRL system in thermal and mechanical hyperalgesia in male and female mice 3-168 h after plantar incision with the use of knock-out (KO) mice with PRL or PRL-R gene ablations and in wild-type (WT) mice. WT mice showed postoperative cold hyperalgesia in a sex-dependent manner (only in females), but with no effect on heat hyperalgesia or mechanical allodynia in either sex. Studies in KO mice showed no effect of PRL and PRL-R gene ablation on heat and cold hyperalgesia in male mice, while heat hyperlgesia were reduced 3-72 h post-surgery in female PRL and PRL-R KO mice. In contrast, PRL and PRL-R ablations significantly attenuated mechanical allodynia 3-72 h post-surgery in both male and female mice. Overall, we found elevated PRL levels in serum, hindpaws and spinal cords after incision, and identify a contributory role for the PRL system in postoperative pain responses to thermal stimuli in females and to mechanical stimuli in both males and females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.