ArticleHuman immunology2013
Identification and validation of shrimp-tropomyosin specific CD4 T cell epitopes.
Article in Human immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Advances in Shellfish Allergy Therapy: From Current Approaches to Future Strategies.Clinical reviews in allergy & immunology · 2025Review
- Molecular Allergology: Epitope Discovery and Its Application for Allergen-Specific Immunotherapy of Food Allergy.Clinical reviews in allergy & immunology · 2025Review
- Toward Consensus Epitopes B and T of Tropomyosin Involved in Cross-Reactivity across Diverse Allergens: An In Silico Study.Biomedicines · 2024Article
- IgE Mediated Shellfish Allergy in Children-A Review.Nutrients · 2023Review
- In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy.Molecules (Basel, Switzerland) · 2022Article
- Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India.Immunogenetics · 2020Article
- Effect of structural stability on endolysosomal degradation and T-cell reactivity of major shrimp allergen tropomyosin.Allergy · 2020Article
- Overcoming Shellfish Allergy: How Far Have We Come?International journal of molecular sciences · 2020Review
- Immunotherapy of Food Allergy: a Comprehensive Review.Clinical reviews in allergy & immunology · 2019Review
- Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region.Scientific reports · 2018Article
- Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands.Frontiers in immunology · 2018Article
- Predicting HLA CD4 Immunogenicity in Human Populations.Frontiers in immunology · 2018Article
- Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Effect of thermal processing on T cell reactivity of shellfish allergens - Discordance with IgE reactivity.PloS one · 2017Article
- Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells.The Journal of allergy and clinical immunology · 2014Article
- Immunization with Hypoallergens of shrimp allergen tropomyosin inhibits shrimp tropomyosin specific IgE reactivity.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundShellfish allergy is an immune-mediated adverse reaction to allergenic shellfish and is responsible for significant morbidity and mortality. CD4 T cell responses play an important role in the pathophysiological mechanisms of sensitization and in production of IgE.
objectiveWe sought to identify and validate CD4 T cell shrimp tropomyosin-derived epitopes and characterize CD4 T cell responses in subjects with a clinical history of shellfish allergy.
methodUsing an in vitro MHC-peptide binding assay, we screened 91 overlapping peptides and identified 28 epitopes with moderate and strong binding capacities; 3 additional peptides were included based on MHC binding prediction score. These peptides were then examined in proliferation and cytokine release assays with T cells from allergic subjects.
result17 epitopes restricted to DRB(∗)01:01, DRB1(∗)03:01, DRB1(∗)04:01, DRB1(∗)09:01, DQB1(∗)02:01, DQB1(∗)03:02 and DQB1(∗)05:01 alleles were identified and validated by both the MHC binding and the functional assays. Two peptides showed specificities to more than one MHC class II allele. We demonstrated that these peptides exert functional responses in an epitope specific manner, eliciting predominantly IL-6 and IL-13.
conclusionThe identified epitopes are specific to common MHC class II alleles in the general population. Our study provides important data for the design of peptide-based immunotherapy of shrimp-allergic patients.
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