Trial reportJournal of critical care2013
The relationship between positive end-expiratory pressure and cardiac index in patients with acute respiratory distress syndrome.
Trial report in Journal of critical care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Right ventricle-specific therapies in acute respiratory distress syndrome: a scoping review.Critical care (London, England) · 2023Article
- High positive end expiratory pressure levels affect hemodynamics in elderly patients with hypertension admitted to the intensive care unit: a prospective cohort study.BMC pulmonary medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeThe purpose of the study is to evaluate the association between positive end-expiratory pressure (PEEP) and cardiac index in patients with acute respiratory distress syndrome (ARDS).
methodsThis is a secondary cross-sectional analysis of the multicenter randomized controlled Fluid and Catheter Treatment Trial enrolling adult patients within 48 hours of ARDS onset. Patients randomized to the pulmonary artery catheter arm, who had PEEP and cardiac index measurements performed within a short period of each other during the first 3 days of the FACTT study enrollment, were included in this study. Because FACTT had a 2 × 2 factorial design, half of the patients were in a "liberal fluids" study arm, and the other half were in a "conservative fluids" study arm.
resultsThe final study population (833 measurements or observations, in 367 patients) was comparable with the original overall FACTT study population. The mean PEEP level used was 8.2 ± 3.4 cm H2O, and the mean cardiac index was 4.2 ± 1.2 L/min per square meter. There was no association between PEEP and cardiac index in patients with ARDS, even when adjusted for Acute Physiology and Chronic Health Evaluation score, age, fluid study arm in FACTT, and sepsis.
conclusionIn patients with ARDS who are managed with liberal or conservative fluid management protocols, PEEP is not associated with lower cardiac index.
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Registered trials
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