ArticleBioorganic & medicinal chemistry2013
New quaternary ammonium camphor derivatives and their antiviral activity, genotoxic effects and cytotoxicity.
Article in Bioorganic & medicinal chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 58 citations in OpenAlex.
- From Biologically Active Complexes with Camphor-Derived Ligands to Biologically Active Biomaterials.Antibiotics (Basel, Switzerland) · 2026Review
- In vitro and in silico analysis of anticancer and antioxidant potential of camphor derivatives.Scientific reports · 2025Article
- Comparative Phytochemical, Colloidal, and Antioxidant Profiling ofMolecules (Basel, Switzerland) · 2025Article
- In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2.Scientific reports · 2025Article
- Exploring the antimicrobial, anti-inflammatory, antioxidant, and immunomodulatory properties ofFrontiers in pharmacology · 2025Review
- The Synthesis and Antibacterial Properties of Pillar[5]arene with Streptocide Fragments.Pharmaceutics · 2023Article
- Medicinal Plants for Viral Respiratory Diseases: A Systematic Review on Persian Medicine.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[ACS infectious diseases · 2022Article
- Traditional Use, Phytochemical Profiles and Pharmacological Properties ofMolecules (Basel, Switzerland) · 2022Review
- Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses.Viruses · 2022Article
- Quaternary ammonium salts based on (-)-borneol as effective inhibitors of influenza virus.Archives of virology · 2021Article
- In vitro inhibitory activity against HPV of the monoterpenoid zinc tetra-ascorbo-camphorate.Heliyon · 2021Article
- Monoterpenes and Their Derivatives-Recent Development in Biological and Medical Applications.International journal of molecular sciences · 2020Review
- Apoptotic Induction and Anti-Migratory Effects ofMolecules (Basel, Switzerland) · 2019Article
- Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.Progress in polymer science · 2017Review
- Synthesis andMedChemComm · 2017Article
- Methacryloxylethyl Cetyl Ammonium Chloride Induces DNA Damage and Apoptosis in Human Dental Pulp Cells via Generation of Oxidative Stress.International journal of biological sciences · 2016Article
- Synthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives.Scientia pharmaceutica · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis and biological evaluation of a novel series of dimeric camphor derivatives are described. The resulting compounds were studied for their antiviral activity, cyto- and genotoxicity. Compounds 3a and 3d in which the quaternary nitrogen atoms are separated by the C5H10 and С9H18 aliphatic chain, exhibited the highest efficiency as an agent inhibiting the reproduction of the influenza virus A(H1N1)pdm09. The cytotoxicity data of compounds 3 and 4 revealed their moderate activity against malignant cell lines; compound 3f had the highest activity for the CEM-13 cells. These results show close agreement with the data of independent studies on toxicity of these compounds, in particular that the toxicity of compounds strongly depends on spacer length.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.