ArticleBiological psychiatry2013
Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The Impact of Mirth-Inducing Ventral Striatal Deep Brain Stimulation on Functional and Effective Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2017Trial
- A human brain network linked to restoration of consciousness after deep brain stimulation.Nature communications · 2025Article
- Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice.Nature communications · 2023Article
- Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study.Therapeutic advances in neurological disorders · 2023Article
- Review
- Centromedian Nucleus of the Thalamus Deep Brain Stimulation for Genetic Generalized Epilepsy: A Case Report and Review of Literature.Frontiers in human neuroscience · 2022Article
- Edge-enhancing gradient echo with multi-image co-registration and averaging (EDGE-MICRA) for targeting thalamic centromedian and parafascicular nuclei.The neuroradiology journal · 2021Article
- Orientation-selective and directional deep brain stimulation in swine assessed by functional MRI at 3T.NeuroImage · 2021Article
- Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals.Frontiers in neuroscience · 2019Article
- Deep brain stimulation in Tourette's syndrome: evidence to date.Neuropsychiatric disease and treatment · 2019Review
- Global network modulation during thalamic stimulation for Tourette syndrome.NeuroImage. Clinical · 2018Article
- Correction of metal-induced susceptibility artifacts for functional MRI during deep brain stimulation.NeuroImage · 2017Article
- Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI.NeuroImage · 2017Article
- The "curved lead pathway" method to enable a single lead to reach any two intracranial targets.Scientific reports · 2017Article
- Functional Circuitry Effect of Ventral Tegmental Area Deep Brain Stimulation: Imaging and Neurochemical Evidence of Mesocortical and Mesolimbic Pathway Modulation.Frontiers in neuroscience · 2017Article
- Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates.Journal of neurophysiology · 2016Article
- Functional correlates of the therapeutic and adverse effects evoked by thalamic stimulation for essential tremor.Brain : a journal of neurology · 2016Article
- Fornix deep brain stimulation circuit effect is dependent on major excitatory transmission via the nucleus accumbens.NeuroImage · 2016Article
- Centromedian-Parafascicular Complex Deep Brain Stimulation for Tourette Syndrome: A Retrospective Study.Mayo Clinic proceedings · 2016Article
- Deep Brain Stimulation for Tourette's Syndrome: The Case for Targeting the Thalamic Centromedian-Parafascicular Complex.Frontiers in neurology · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDeep brain stimulation (DBS) of the centromedian-parafascicular (CM-Pf) thalamic nuclei has been considered an option for treating Tourette syndrome. Using a large animal DBS model, this study was designed to explore the network effects of CM-Pf DBS.
methodsThe combination of DBS and functional magnetic resonance imaging is a powerful means of tracing brain circuitry and testing the modulatory effects of electrical stimulation on a neuronal network in vivo. With a within-subjects design, we tested the proportional effects of CM and Pf DBS by manipulating current spread and varying stimulation contacts in healthy pigs (n = 5).
resultsOur results suggests that CM-Pf DBS has an inhibitory modulating effect in areas that have been suggested as contributing to impaired sensory-motor and emotional processing. The results also help to define the differential neural circuitry effects of the CM and Pf with evidence of prominent sensorimotor/associative effects for CM DBS and prominent limbic/associative effects for Pf DBS.
conclusionsOur results support the notion that stimulation of deep brain structures, such as the CM-Pf, modulates multiple networks with cortical effects. The networks affected by CM-Pf stimulation in this study reinforce the conceptualization of Tourette syndrome as a condition with psychiatric and motor symptoms and of CM-Pf DBS as a potentially effective tool for treating both types of symptoms.
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