ArticlePhytochemistry2013
The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction.
Article in Phytochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- The inhibition of pathological IgE in allergic diseases by natural compounds.Natural products and bioprospecting · 2026Review
- Physician attitudes toward natural syrup formulations for cough and sore throat: a multinational cross-sectional survey of 398 healthcare professionals across 13 countries.Frontiers in pharmacology · 2026Article
- Flavonoids as potential anti-asthmatic agents.Frontiers in immunology · 2026Review
- Traditional Chinese Medicine for Pediatric Allergic Diseases.Current allergy and asthma reports · 2025Review
- Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties.Molecules (Basel, Switzerland) · 2025Review
- Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect.Evidence-based complementary and alternative medicine : eCAM · 2024Review
- Determination of Antioxidant, Cytotoxicity, and Acetylcholinesterase Inhibitory Activities of Alkaloids Isolated fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Efficacy of Kushen decoction on high-fat-diet-induced hyperlipidemia in rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Formononetin isolated fromFrontiers in allergy · 2022Article
- Article
- Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know.Frontiers in pharmacology · 2019Review
- Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.International journal of molecular sciences · 2018Review
- Immune Homeostasis: Effects of Chinese Herbal Formulae and Herb-Derived Compounds on Allergic Asthma in Different Experimental Models.Chinese journal of integrative medicine · 2018Review
- Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the βBrain, behavior, and immunity · 2018Article
- Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA²LEN Study.Nutrients · 2018Article
- Nelumbo nucifera leaves extracts inhibit mouse airway smooth muscle contraction.BMC complementary and alternative medicine · 2017Article
- The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations.International journal of molecular sciences · 2017Article
- ETHNOBOTANICAL STUDY OF PLANTS USED TO TREAT ASTHMA IN THE MARITIME REGION IN TOGO.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications.Mediators of inflammation · 2016Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Asthma is a serious health problem worldwide, particularly in industrialized countries. Despite a better understanding of the pathophysiology of asthma, there are still considerable gaps in knowledge as well as a need for classes of drugs. ASHMI™ (Anti-asthma Herbal Medicine Intervention) is an aqueous extract of Ganoderma lucidum (Fr.) P. Karst (Ling Zhi), Sophora flavescens Aiton (Ku Shen) and Glycyrrhiza uralensis Fisch. ex DC (Gan Cao). It prevents allergic asthma airway hyper-reactivity in mice and inhibits acetylcholine (ACh) induced airway smooth muscle (ASM) contraction in tracheal rings from allergic asthmatic mice. The purpose of this research was to identify individual herb(s) and their active compound(s) that inhibit ASM contraction. It was found that S. flavescens, but not G. lucidum or G. uralensis aqueous extracts, inhibited ASM contraction in tracheal rings from asthmatic mice. Bioassay-guided isolation and identification of flavonoid fractions/compound(s) via methylene chloride extraction, preparative HPLC fractionation, and LC-MS and NMR spectroscopic analyses showed that trifolirhizin is an active constituent that inhibits acetylcholine mediated ASM contraction or directly relaxes pre-contracted ASM independent of β2-adrenoceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.