ArticleArchives of gerontology and geriatrics
Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver.
Article in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Molecular Responses to Temperature Changes Across Timescales in the Madagascar Ground Gecko (Paroedura picta).Molecular ecology · 2026Article
- Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure.International journal of medical sciences · 2023Article
- Article
- Sexual dimorphism in the hepatic protein response to a moderate trans fat diet in senescence-accelerated mice.Lipids in health and disease · 2017Article
- Anemia in the frail, elderly patient.Clinical interventions in aging · 2016Review
- Aging impairs induction of redox factor-1 after heat stress: a potential mechanism for heat-induced liver injury.International journal of physiology, pathophysiology and pharmacology · 2015Article
- C/EBPα inhibits proliferation of breast cancer cells via a novel pathway of miR-134/CREB.International journal of clinical and experimental pathology · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Elevations in hepatic iron content occur with aging and physiological stressors, which may promote oxidative injury to the liver. Since dysregulation of the iron regulatory hormone, hepcidin, can cause iron accumulation, our goal was to characterize the regulation of hepcidin in young (6 mo) and old (24 mo) Fischer 344 rats exposed to environmental heat stress. Liver and blood samples were taken in the control condition and after heating. Hepcidin expression did not differ between young and old rats in the control condition, despite higher levels of hepatic iron and IL-6 mRNA in the latter. Following heat stress, pSTAT3 increased in both groups, but C/EBPα and hepcidin mRNA increased only in old rats. Despite this, serum iron decreased in both age groups 2 h after heat stress, suggesting hepcidin-independent hypoferremia in the young rats. The differential regulation of hepcidin between young and old rats after hyperthermia may be due to the enhanced expression of C/EBPα protein in old rats. These data support the concept of "inflammaging" and suggest that repeated exposures to stressors may contribute to the development of anemia in older individuals.
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