ArticleStress (Amsterdam, Netherlands)2013
Stressor-specific effects of sex on HPA axis hormones and activation of stress-related neurocircuitry.
Article in Stress (Amsterdam, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Article
- Concurrent consumption of ethanol and corticosterone during adolescence alters neuroimmune sensitivity in Sprague Dawley rats.Addiction neuroscience · 2025Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- Acute stress facilitates habitual behavior in female rats.Physiology & behavior · 2024Article
- Sexual dimorphism in anxiety is programmed in-utero by sex-steroids: Proof of concept using a disease-model and stress responses to COVID pandemic.Psychiatry research · 2024Article
- Serum-Derived Neuronal Exosomal microRNAs as Stress-Related Biomarkers in an Atopic Dermatitis Model.Biomedicines · 2021Article
- Serum-Derived Neuronal Exosomal miRNAs as Biomarkers of Acute Severe Stress.International journal of molecular sciences · 2021Article
- Androgens and Their Role in Regulating Sex Differences in the Hypothalamic/Pituitary/Adrenal Axis Stress Response and Stress-Related Behaviors.Androgens: clinical research and therapeutics · 2021Review
- Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice.Physiology & behavior · 2020Article
- Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.Biology of sex differences · 2020Review
- Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation.Brain sciences · 2020Review
- Fetal growth outcomes following peri-implantation exposure of Long-Evans rats to noise and ozone differ by sex.Biology of sex differences · 2019Article
- Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?International journal of molecular sciences · 2019Review
- High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology.BMC systems biology · 2018Article
- Article
- A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.Nature communications · 2017Article
- A users guide to HPA axis research.Physiology & behavior · 2017Review
- Developmental stress and social phenotypes: integrating neuroendocrine, behavioural and evolutionary perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Sex in the brain: hormones and sex differences.Dialogues in clinical neuroscience · 2016Review
- Apparatus and General Methods for Exposing Rats to Audiogenic Stress.Bio-protocol · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Experiencing stress can be physically and psychologically debilitating to an organism. Women have a higher prevalence of some stress-related mental illnesses, the reasons for which are unknown. These experiments explore differential HPA axis hormone release in male and female rats following acute stress. Female rats had a similar threshold of HPA axis hormone release following low intensity noise stress as male rats. Sex did not affect the acute release, or the return of HPA axis hormones to baseline following moderate intensity noise stress. Sensitive indices of auditory functioning obtained by modulation of the acoustic startle reflex by weak pre-pulses did not reveal any sexual dimorphism. Furthermore, male and female rats exhibited similar c-fos mRNA expression in the brain following noise stress, including several sex-influenced stress-related regions. The HPA axis response to noise stress was not affected by stage of estrous cycle, and ovariectomy significantly increased hormone release. Direct comparison of HPA axis hormone release to two different stressors in the same animals revealed that although female rats exhibit robustly higher HPA axis hormone release after restraint stress, the same effect was not observed following moderate and high intensity loud noise stress. Finally, the differential effect of sex on HPA axis responses to noise and restraint stress cannot readily be explained by differential social cues or general pain processing. These studies suggest the effect of sex on acute stress-induced HPA axis hormone activity is highly dependent on the type of stressor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.