ArticleThe European journal of neuroscience2013
Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study.
Article in The European journal of neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Bimodal nonlinear dendrites in PV+ basket cells drive distinct memory-related oscillations.iScience · 2025Article
- Gamma oscillation plasticity is mediated via parvalbumin interneurons.Science advances · 2024Article
- A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells.Bioengineered · 2021Article
- Synaptic entrainment of ectopic action potential generation in hippocampal pyramidal neurons.The Journal of physiology · 2018Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- Memory replay in balanced recurrent networks.PLoS computational biology · 2017Article
- From Neuron Biophysics to Orientation Selectivity in Electrically Coupled Networks of Neocortical L2/3 Large Basket Cells.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Article
- A Unified Dynamic Model for Learning, Replay, and Sharp-Wave/Ripples.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Memory trace replay: the shaping of memory consolidation by neuromodulation.Trends in neurosciences · 2015Review
- Action potential generation in an anatomically constrained model of medial superior olive axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Re-encoding of associations by recurrent plasticity increases memory capacity.Frontiers in synaptic neuroscience · 2014Article
- A computational model for preplay in the hippocampus.Frontiers in computational neuroscience · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms of place cell replay occurring during sharp-wave ripples (SPW-Rs) remain obscure due to the fact that ripples in vitro depend on non-synaptic mechanisms, presumably via axo-axonal gap junctions between pyramidal cells. We suggest a model of in vivo SPW-Rs in which synaptic excitatory post-synaptic potentials (EPSPs) control the axonal spiking of cells in SPW-Rs: ripple activity remains hidden in the network of axonal collaterals (connected by gap junctions) due to conduction failures, unless there is a sufficient dendritic EPSP. The EPSP brings the axonal branching point to threshold, and action potentials from the collateral start to propagate to the soma and to the distal axon. The model coherently explains multiple experimental data on SPW-Rs, both in vitro and in vivo. The mechanism of synaptic gating leads to the following implication: a sequence of pyramidal cells can be replayed at ripple frequency by the superposition of subthreshold dendritic EPSPs and ripple activity in the axonal plexus. Replay is demonstrated in both forward and reverse directions. We discuss several testable predictions. In general, the mechanism of synaptic gating suggests that pyramidal cells under certain conditions can act like a transistor.
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