ReviewAntioxidants & redox signaling2014
Reactive oxygen species in inflammation and tissue injury.
Review in Antioxidants & redox signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07433907 (A Prospective, Randomized, Split-Face Pilot Study Comparing the Efficacy of the Institute of Dermatology's Antioxidant Moisturizing Serum in Mild to Moderate Seborrheic Dermatitis), which is not on this map. Cited by 2,306 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Split-Face Pilot Study Comparing the Efficacy of the Institute of Dermatology's Antioxidant Moisturizing Serum in Mild to Moderate Seborrheic Dermatitis
Who cites it
2,306 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues.Cell proliferation · 2026Pooled it
- Antinociceptive activity of Laportea species mediated by anti-inflammatory and antioxidant mechanisms: a systematic review and meta-analysis of in vivo animal studies.BMC complementary medicine and therapies · 2026Pooled it
- The relationship between motor and cognitive performance and cortical activity in patients with multiple sclerosis: a systematic review of functional near-infrared spectroscopy studies.Frontiers in rehabilitation sciences · 2026Pooled it
- Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.Gut microbes · 2026Article
- Redox protection by bacterial glutathione peroxidase drives virulence inRedox report : communications in free radical research · 2026Article
- Reactive oxygen species (ROS) research in drug discovery and drug delivery: Can the medium Be a Trojan Horse disguised as something benign?Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Review
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- An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair.Bioactive materials · 2026Article
- Efficacy of atopic dermatitis alleviation through transcutaneous auricular vagus nerve stimulation in 2,4-dinitrochlorobenzene (DNCB)-induced mouse model.Annals of medicine · 2026Article
- Analysis of the sorghumGM crops & food · 2026Article
- Molecular modulation of cartilage graft survival: a systematic review and translational synthesis of local and systemic strategies.JPRAS open · 2026Review
- Evaluation of the anti-inflammatory potentials of ethanol leaf extract of Vigna unguiculata in Wistar rats.Inflammopharmacology · 2026Article
- Redox imbalance in urology: mechanistic insights into the development and progression of selected urological conditions.Biology direct · 2026Review
- Antioxidant Activity and Anti-Inflammatory Potential ofPlants (Basel, Switzerland) · 2026Article
- Association between polyphenols and inhalation-induced oxidative stress in chronic lung diseases: A systematic review.Biomedical reports · 2026Article
- Compartment-specific Zinc Misallocation in Diabetic Foot Ulcers: Mechanistic Coupling Between Macrophage M1 Locking and MMP-9 Hyperactivation.Biological trace element research · 2026Review
- Short-Term Alterations in Thiol-Disulfide Homeostasis Following ERCP: A Prospective Controlled Study.Digestive diseases and sciences · 2026Observational
- Endothelial ADAM17 facilitates neutrophil migration and pulmonary microvascular permeability in acute lung inflammation.Journal of biomedical science · 2026Article
2,246 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Abstract Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS generation by polymorphonuclear neutrophils (PMNs) at the site of inflammation causes endothelial dysfunction and tissue injury. The vascular endothelium plays an important role in passage of macromolecules and inflammatory cells from the blood to tissue. Under the inflammatory conditions, oxidative stress produced by PMNs leads to the opening of inter-endothelial junctions and promotes the migration of inflammatory cells across the endothelial barrier. The migrated inflammatory cells not only help in the clearance of pathogens and foreign particles but also lead to tissue injury. The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.