SynthesisHPB : the official journal of the International Hepato Pancreato Biliary Association2014
Systematic review of pathophysiological changes following hepatic resection.
Synthesis in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05361252 (Restrictive Versus Liberal Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Restrictive Versus Liberal Stroke Volume Variation-guided Fluid Infusion in Major Liver Tumour Resection: a Prospective Randomised Trial of Perioperative Quality of Care
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Markers of liver regeneration-the role of growth factors and cytokines: a systematic review.BMC surgery · 2020Pooled it
- The role of liver stiffness measurement in predicting Long-term liver function after partial hepatectomy.Abdominal radiology (New York) · 2026Article
- Successful management of acute intraoperative hyperkalemia during huge liver cancer resection following neoadjuvant chemotherapy: a case report.AME case reports · 2026Article
- Impact of neoadjuvant cetuximab on liver function and tumor reduction in a murine model of selective portal vein ligation.Clinical & experimental metastasis · 2025Article
- Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes.World journal of gastrointestinal pathophysiology · 2025Article
- Prospective Analysis of Perioperative Stress Response in Living Donor Liver Transplantation for Hepatitis B-Related Liver Disease.Journal of clinical medicine · 2025Article
- Letter to the Editor.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Early postoperative liver function parameters as predictors of post-hepatectomy liver failure.Frontiers in surgery · 2025Article
- Experimental study and clinical significance of the impact of gastrointestinal motility disorders on hepatic blood perfusion.Frontiers in medicine · 2025Article
- Phase I trial of single-photon emission computed tomography-guided liver-directed radiotherapy for patients with low functional liver volume.JNCI cancer spectrum · 2024Article
- In Vitro Human Liver Model for Toxicity Assessment with Clinical and Preclinical Instrumentation.Pharmaceutics · 2024Article
- Lidocaine clearance as pharmacokinetic parameter of metabolic hepatic activity in patients with impaired liver.Journal of medical biochemistry · 2023Article
- Multi-parametric magnetic resonance imaging of liver regeneration in a standardized partial hepatectomy rat model.BMC gastroenterology · 2022Article
- Routine Postoperative Antibiotic Prophylaxis Offers No Benefit after Hepatectomy-A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2022Review
- Lean body mass predicts postoperative liver failure in patients with hepatocellular carcinoma.Cancer biomarkers : section A of Disease markers · 2022Article
- Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.The American journal of pathology · 2019Article
- The molecular adsorbent recirculating system in posthepatectomy liver failure: Results from a prospective phase I study.Hepatology communications · 2018Article
- Computational Modeling in Liver Surgery.Frontiers in physiology · 2017Review
- Impact of Perioperative Phosphorus and Glucose Levels on Liver Regeneration and Long-term Outcomes after Major Liver Resection.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- Differences in Perioperative Outcomes Between Right and Left Hepatic Lobectomy.Indian journal of surgical oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMajor hepatic resection is now performed frequently and with relative safety, but is accompanied by significant pathophysiological changes. The aim of this review is to describe these changes along with interventions that may help reduce the risk for adverse outcomes after major hepatic resection.
methodsThe MEDLINE, EMBASE and CENTRAL databases were searched for relevant literature published from January 2000 to December 2011. Broad subject headings were 'hepatectomy/', 'liver function/', 'liver failure/' and 'physiology/'.
resultsPredictable changes in blood biochemistry and coagulation occur following major hepatic resection and alterations from the expected path indicate a complicated course. Susceptibility to sepsis, functional renal impairment, and altered energy metabolism are important sequelae of post-resection liver failure.
conclusionsThe pathophysiology of post-resection liver failure is difficult to reverse and thus strategies aimed at prevention are key to reducing morbidity and mortality after liver surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.