ArticleJournal of the American Chemical Society2013
Enhanced aqueous Suzuki-Miyaura coupling allows site-specific polypeptide 18F-labeling.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Transformation-Guided Genome Mining Provides Access to Brominated Lanthipeptides.Organic letters · 2025Article
- Genome mining for the discovery of peptide halogenases and their biochemical characterization.Methods in enzymology · 2025Article
- Deoxyfluorination of phenols for chemoselectiveNature protocols · 2023Review
- A Leader-Guided Substrate Tolerant RiPP Brominase Allows Suzuki-Miyaura Cross-Coupling Reactions for Peptides and Proteins.Biochemistry · 2023Article
- Broad-scope Syntheses of [Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Aryl diazonium intermediates enable mild DNA-compatible C-C bond formation for medicinally relevant combinatorial library synthesis.Chemical science · 2022Article
- An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins.Royal Society open science · 2022Article
- Closing the gap betweenEJNMMI radiopharmacy and chemistry · 2021Review
- Halogenases: a palette of emerging opportunities for synthetic biology-synthetic chemistry and C-H functionalisation.Chemical Society reviews · 2021Review
- Artificial Organelles: Towards Adding or Restoring Intracellular Activity.Chembiochem : a European journal of chemical biology · 2021Review
- Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling.Analytical chemistry · 2021Article
- Suzuki-Miyaura Cross-Coupling of Bromotryptophan Derivatives at Ambient Temperature.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Article
- Concepts of Catalysis in Site-Selective Protein Modifications.Journal of the American Chemical Society · 2019Review
- Hollow nanoreactors for Pd-catalyzed Suzuki-Miyaura coupling andChemical science · 2019Article
- Review
- Review
- SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts.Angewandte Chemie (International ed. in English) · 2017Article
- Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo.Nature communications · 2017Article
- Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.ACS chemical biology · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
The excesses of reagents used in protein chemistry are often incompatible with the reduced or even inverse stoichiometries used for efficient radiolabeling. Analysis and screening of aqueous Pd(0) ligand systems has revealed the importance of a guanidine core and the discovery of 1,1-dimethylguanidine as an enhanced ligand for aqueous Suzuki-Miyaura cross-coupling. This novel Pd catalyst system has now allowed the labeling of small molecules, peptides, and proteins with the fluorine-18 prosthetic [(18)F]4-fluorophenylboronic acid. These findings now enable site-specific protein (18)F-labeling under biologically compatible conditions using a metal-triggered reaction.
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