ArticleBioMed research international2013
Promotion of hepatic differentiation of bone marrow mesenchymal stem cells on decellularized cell-deposited extracellular matrix.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- [Liver engineering as a new source of donor organs : A systematic review].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016Pooled it
- Mesenchymal Stem Cell Immunomodulation: A Novel Intervention Mechanism in Cardiovascular Disease.Frontiers in cell and developmental biology · 2021Review
- Long Non-coding RNA Regulation of Mesenchymal Stem Cell Homeostasis and Differentiation: Advances, Challenges, and Perspectives.Frontiers in cell and developmental biology · 2021Review
- In vitro efficacy of liver microenvironment in bone marrow mesenchymal stem cell differentiation.In vitro cellular & developmental biology. Animal · 2020Article
- Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters.Acta biomaterialia · 2019Article
- Long noncoding RNA ANCR inhibits the differentiation of mesenchymal stem cells toward definitive endoderm by facilitating the association of PTBP1 with ID2.Cell death & disease · 2019Article
- Mesenchymal stem cells and immune disorders: from basic science to clinical transition.Frontiers of medicine · 2019Review
- Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species.Acta biomaterialia · 2018Article
- SIRT1-dependent anti-senescence effects of cell-deposited matrix on human umbilical cord mesenchymal stem cells.Journal of tissue engineering and regenerative medicine · 2018Article
- Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells.Biomaterials research · 2018Article
- Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signalling.Journal of cellular and molecular medicine · 2017Article
- Effects of Human Fibroblast-Derived Extracellular Matrix on Mesenchymal Stem Cells.Stem cell reviews and reports · 2016Article
- Decellularized spleen matrix for reengineering functional hepatic-like tissue based on bone marrow mesenchymal stem cells.Organogenesis · 2016Article
- Culturing on decellularized extracellular matrix enhances antioxidant properties of human umbilical cord-derived mesenchymal stem cells.Materials science & engineering. C, Materials for biological applications · 2016Article
- Laminin matrix promotes hepatogenic terminal differentiation of human bone marrow mesenchymal stem cells.Iranian journal of basic medical sciences · 2016Article
- A comparison of the chemical and liver extract-induced hepatic differentiation of adipose derived stem cells.In vitro cellular & developmental biology. Animal · 2015Article
- Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.Journal of pineal research · 2015Article
- In Vitro and In Vivo Hepatic Differentiation of Adult Somatic Stem Cells and Extraembryonic Stem Cells for Treating End Stage Liver Diseases.Stem cells international · 2015Review
- Acoustic-frequency vibratory stimulation regulates the balance between osteogenesis and adipogenesis of human bone marrow-derived mesenchymal stem cells.BioMed research international · 2015Article
- Response of endothelial cells to decellularized extracellular matrix deposited by bone marrow mesenchymal stem cells.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between stem cells and extracellular matrix (ECM) are requisite for inducing lineage-specific differentiation and maintaining biological functions of mesenchymal stem cells by providing a composite set of chemical and structural signals. Here we investigated if cell-deposited ECM mimicked in vivo liver's stem cell microenvironment and facilitated hepatogenic maturation. Decellularization process preserved the fibrillar microstructure and a mix of matrix proteins in cell-deposited ECM, such as type I collagen, type III collagen, fibronectin, and laminin that were identical to those found in native liver. Compared with the cells on tissue culture polystyrene (TCPS), bone marrow mesenchymal stem cells (BM-MSCs) cultured on cell-deposited ECM showed a spindle-like shape, a robust proliferative capacity, and a suppressed level of intracellular reactive oxygen species, accompanied with upregulation of two superoxide dismutases. Hepatocyte-like cells differentiated from BM-MSCs on ECM were determined with a more intensive staining of glycogen storage, an elevated level of urea biosynthesis, and higher expressions of hepatocyte-specific genes in contrast to those on TCPS. These results demonstrate that cell-deposited ECM can be an effective method to facilitate hepatic maturation of BM-MSCs and promote stem-cell-based liver regenerative medicine.
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