ArticlePloS one2013
Pre-existing hypoxia is associated with greater EEG suppression and early onset of evolving seizure activity during brief repeated asphyxia in near-term fetal sheep.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Article
- Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy.JAMA network open · 2024Article
- Duration of birth depression and neurodevelopmental outcomes after whole-body hypothermia for hypoxic ischemic encephalopathy in India, Sri Lanka and Bangladesh - an exploratory analysis of the HELIX trial.The Lancet regional health. Southeast Asia · 2024Article
- Fetal brain response to worsening acidosis: an experimental study in a fetal sheep model of umbilical cord occlusions.Scientific reports · 2023Article
- Prediction of Fetal Blood Pressure during Labour with Deep Learning Techniques.Bioengineering (Basel, Switzerland) · 2023Article
- Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses.Frontiers in physiology · 2022Review
- The fetus at the tipping point: modifying the outcome of fetal asphyxia.The Journal of physiology · 2018Review
- The peripheral chemoreflex: indefatigable guardian of fetal physiological adaptation to labour.The Journal of physiology · 2018Review
- Cerebral economics: shedding light on supply and demand in the developing brain.The Journal of physiology · 2017Article
- The myths and physiology surrounding intrapartum decelerations: the critical role of the peripheral chemoreflex.The Journal of physiology · 2016Review
- Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings.Journal of visualized experiments : JoVE · 2015Article
- Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus.Physiological reports · 2015Article
- Online detection of fetal acidemia during labour by testing synchronization of EEG and heart rate: a prospective study in fetal sheep.PloS one · 2014Article
- Adaptive brain shut-down counteracts neuroinflammation in the near-term ovine fetus.Frontiers in neurology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous antenatal hypoxia is associated with high risk of adverse outcomes, however, there is little information on neural adaptation to labor-like insults. Chronically instrumented near-term sheep fetuses (125 ± 3 days, mean ± SEM) with baseline PaO2 < 17 mmHg (hypoxic group: n = 8) or > 17 mmHg (normoxic group: n = 8) received 1-minute umbilical cord occlusions repeated every 5 minutes for a total of 4 hours, or until mean arterial blood pressure (MAP) fell below 20 mmHg for two successive occlusions. 5/8 fetuses with pre-existing hypoxia were unable to complete the full series of occlusions (vs. 0/8 normoxic fetuses). Pre-existing hypoxia was associated with progressive metabolic acidosis (nadir: pH 7.08 ± 0.04 vs. 7.33 ± 0.02, p<0.01), hypotension during occlusions (nadir: 24.7 ± 1.8 vs. 51.4 ± 3.2 mmHg, p<0.01), lower carotid blood flow during occlusions (23.6 ± 6.1 vs. 63.0 ± 4.8 mL/min, p<0.01), greater suppression of EEG activity during, between, and after occlusions (p<0.01) and slower resolution of cortical impedance, an index of cytotoxic edema. No normoxic fetuses, but 4/8 hypoxic fetuses developed seizures 148 ± 45 minutes after the start of occlusions, with a seizure burden of 26 ± 6 sec during the inter-occlusion period, and 15.1 ± 3.4 min/h in the first 6 hours of recovery. In conclusion, in fetuses with pre-existing hypoxia, repeated brief asphyxia at a rate consistent with early labor is associated with hypotension, cephalic hypoperfusion, greater EEG suppression, inter-occlusion seizures, and more sustained cytotoxic edema, consistent with early onset of neural injury.
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